General
Preferred name
(RS)-AMPA
Synonyms
(S)-AMPA ()
(±)-AMPA hydrobromide ()
(RS)-AMPA hydrobromide ()
AMPA ()
[3H]AMPA ()
(RS)-AMPA (hydrobromide) ()
(RS)-AMPA (monohydrate) ()
(±)-AMPA ()
(±)-AMPA (hydrobromide) ()
(±)-AMPA (monohydrate) ()
(R,S)-AMPA ()
(¡À)-AMPA (hydrobromide) ()
(R,S)-AMPA (hydrate) ()
P&D ID
PD019051
CAS
77521-29-0
171259-81-7
110592-37-5
74341-63-2
118896-96-1
76463-67-7
Tags
available
drug candidate
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION (RS)-AMPA ((¡À)-AMPA) hydrobromide is a glutamate analogue and a potent and selective excitatory neurotransmitter L-glutamic acid agonist. (RS)-AMPA hydrobromide does not interfere with binding sites for kainic acid or NMDA receptors[1][2].
DESCRIPTION Potent NMDA antagonist (Tocris Bioactive Compound Library)
DESCRIPTION Selective AMPA agonist (Tocriscreen Total)
DESCRIPTION AMPA is the defining agonist for the AMPA subgroup of ionotropic glutamate receptors, which mediate excitatory neurotransmission. (BOC Sciences Bioactive Compounds)
DESCRIPTION (RS)-AMPA has been found to be a definitive agonist of the AMPA glutamatergic ionotropic receptor. (BOC Sciences Bioactive Compounds)
DESCRIPTION CaV1.x blocker (Tocris Bioactive Compound Library)
DESCRIPTION Potent excitatory amino acid that interacts selectively with central AMPA/kainate glutamate receptors (LOPAC library)
DESCRIPTION Selective AMPA agonist. More water soluble form of (RS)-AMPA (Cat. No. 0169) (Tocriscreen Total)
DESCRIPTION The hydrobromide salt form of (RS)-AMPA, which has been found to be an agonist of the excitatory neurotransmitter L-glutamic Acid. (BOC Sciences Bioactive Compounds)
Cell lines
0
Organisms
2
Compound Sets
19
Axon Medchem Screening Library
3415
BOC Sciences Bioactive Compounds
4-isoxazolepropanoicacid-a-amino-2-3-dihydro-5-methyl-3-oxo-cas-77521-29-0-item-42988
rs-ampa-cas-74341-63-2-379075
rs-ampa-hydrobromide-cas-171259-81-7-item-117226
Cayman Chemical Bioactives
14571
Concise Guide to Pharmacology 2017/18
4077
4131
Concise Guide to Pharmacology 2019/20
4077
4131
Concise Guide to Pharmacology 2021/22
4077
4131
Concise Guide to Pharmacology 2023/24
4077
4131
CZ-OPENSCREEN Bioactive Library
DrugMAP
DMLF7SG
DrugMatrix
EUbOPEN Chemogenomics Library
EUB0001990
Guide to Pharmacology
4077
4131
Ki Database
AMPA
LOPAC library
Mcule NIBR MoA Box Subset
MCULE-8572875801
MedChem Express Bioactive Compound Library
HY-100815B
HY-100815C
HY-100815D
Novartis Chemogenetic Library (NIBR MoA Box)
Tocris Bioactive Compound Library
0169
1074
Tocriscreen Total
External IDs
47
Properties
(calculated by RDKit )
Molecular Weight
186.06
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
3
Ring Count
1
Aromatic Ring Count
1
cLogP
-0.36
TPSA
109.58
Fraction CSP3
0.43
Chiral centers
1.0
Largest ring
5.0
QED
0.59
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
AMPA/kainate
Primary Target
AMPA Receptors
MOA
Agonist
Member status
member
Target
AMPA agonist
iGluR
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Recommended Cell Concentration
1 uM
Source data