General
Preferred name
BAY 41-2272
Synonyms
BAY412272 ()
P&D ID
PD018998
CAS
256376-24-6
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION BAY 41-2272 is an orally active and soluble guanylate cyclases (sGC) activator, which increases sGC activity by 400-fold in synergy with NO. BAY 41-2272 potently unloaded the heart, increased cardiac output, thus can be used for cardiovascular diseases research[1][2].
PRICE 60
DESCRIPTION Highly potent, selective GSK-3 inhibitor (Tocris Bioactive Compound Library)
DESCRIPTION Soluble guanylyl cyclase (sGC) activator (Tocriscreen Plus)
DESCRIPTION BAY 41-2272 is a direct and NO-independent soluble guanylate cyclase (sGC) stimulator. (TargetMol Bioactive Compound Library)
Compound Sets
11
Cayman Chemical Bioactives
10057
Drug Repurposing Hub
DrugMAP
DM0M59T
EUbOPEN Chemogenomics Library
EUB0001658
Guide to Pharmacology
5146
MedChem Express Bioactive Compound Library
HY-12376
ReFrame library
Selleckchem Bioactive Compound Library
bay-41-2272
TargetMol Bioactive Compound Library
T6775
Tocris Bioactive Compound Library
4430
Tocriscreen Plus
4430
External IDs
31
Properties
(calculated by RDKit )
Molecular Weight
360.15
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
5
Aromatic Ring Count
4
cLogP
3.54
TPSA
82.51
Fraction CSP3
0.2
Chiral centers
0.0
Largest ring
6.0
QED
0.6
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Target
Guanylate Cyclase
GUCY1A3, GUCY1B3
Primary Target
Guanylyl Cyclases
MOA
Activator
guanylyl cyclase activator
Pathway
GPCR/G protein
Recommended Cell Concentration
None
Source data