General
Preferred name
Lutidinic Acid
Synonyms
Pyridine-2,4-Dicarboxylic Acid, 2,4-Pyridine Dicarboxylic Acid ()
2,4-Pyridinedicarboxylic Acid ()
2,4-Dicarboxypyridine ()
2, 4-PDCA ()
2,4-PDCA ()
Pyridine-2,4-dicarboxylic acid ()
Lutidinic Acid, 2,4-Dicarboxypyridine, 2,4-PDCA ()
2,4-Pyridinedicarboxylic acid monohydrate ()
2,4-Pyridinedicarboxylic Acid (hydrate) ()
compound 6a [PMID: 18942826] ()
P&D ID
PD018894
CAS
499-80-9
207671-42-9
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Compound 6a inhibits the demethylase activity of lysine (K)-specific demethylase 4E (KDM4E, a.k.a. JMJD2E) and lysine (K)-specific demethylase 4A (KDM4A, a.k.a. JMJD2A) . (GtoPdb)
DESCRIPTION 2,4-PDCA (2,4 pyridine dicarboxylic acid) is a broad-spectrum inhibitor of 2OG oxygenase, including JmjC domain-containing family of histone demethylases (JHDMs). 2,4-PDCA is a target chemical in the field of bio-based plastics[1][2][3].
PRICE 29
DESCRIPTION 2,4-PDCA is a broad-spectrum inhibitor of 2OG oxygenase, including JmjC domain-containing family of histone demethylases. (Enamine Bioactive Compounds)
DESCRIPTION lutidinic acid (2,4-Dicarboxypyridine) is an in vitro and in cell inhibitor, as well as a known inhibitor of the histone lysine demethylases. (TargetMol Bioactive Compound Library)
DESCRIPTION 2,4-Pyridinedicarboxylic acid (2,4-PDCA) is a compound that structurally mimics 2-oxoglutarate (2-OG, also known as α-ketoglutarate) and chelates zinc, thus affecting a range of enzymes. (BOC Sciences Bioactive Compounds)
Compound Sets
10
BOC Sciences Bioactive Compounds
2-4-pyridinedicarboxylic-acid-monohydrate-cas-207671-42-9-292082
Cayman Chemical Bioactives
11138
DrugMAP
DM4G8WX
Enamine Bioactive Compounds
EBC-152074
EU-OPENSCREEN Bioactive Compound Library
EOS101881
Guide to Pharmacology
8744
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL316034
MedChem Express Bioactive Compound Library
HY-W017132
Selleckchem Bioactive Compound Library
pyridinedicarboxylic-acid
TargetMol Bioactive Compound Library
T2167
External IDs
36
Properties
(calculated by RDKit )
Molecular Weight
167.02
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
1
Aromatic Ring Count
1
cLogP
0.48
TPSA
87.49
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.67
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
histone lysine demethylases
Histone Demethylase
Pathway
Chromatin/Epigenetic
Epigenetics
Source data