General
Preferred name
Tetrahydroharmine
Synonyms
Leptaflorine ()
P&D ID
PD018819
CAS
17019-01-1
Tags
available
natural product
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Tetrahydroharmine (Leptaflorine) is A monoamine oxidase (MAO) inhibitor with a IC50 value of 74 nM for MAO-A. Tetrahydroharmine can be used in the study of neurodegenerative diseases[1].
PRICE 41
DESCRIPTION Tetrahydroharmine is a plant-derived β-carboline alkaloid that is a component of the psychoactive drink Ayahuasca, that is traditionally brewed by indigenous cultures in the Amazon. It is one of the harmala alkaloids produced by plants such as Banisteriopsis caapi and Peganum harmala. Pharmacologically tetrahydroharmine acts to prevent the breakdown of Ayahuasca's principal hallucinogenic substance (DMT) by reversibly inhibiting monoamine oxidase A (MAO-A) . (GtoPdb)
DESCRIPTION Tetrahydroharmine (Leptaflorine) is a natural product found in the stems and large branches of Banisteriopsis caapi cultivar Da Vine. Tetrahydroharmine is a Monoamine oxidase A inhibitor. (TargetMol Bioactive Compound Library)
Compound Sets
5
Cayman Chemical Bioactives
35037
14449
Guide to Pharmacology
13141
MedChem Express Bioactive Compound Library
HY-125515
Selleckchem Bioactive Compound Library
tetrahydroharmine
TargetMol Bioactive Compound Library
TN7211
External IDs
19
Properties
(calculated by RDKit )
Molecular Weight
216.13
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
3
Aromatic Ring Count
2
cLogP
2.38
TPSA
37.05
Fraction CSP3
0.38
Chiral centers
1.0
Largest ring
6.0
QED
0.77
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
MAO-A
Monoamine Oxidase
MAO
Pathway
Neuronal Signaling
Metabolism
Neuroscience
Source data