General
Preferred name
LY341495
Synonyms
LY 341495 ()
[3H]LY341495 ()
[3H]LY341495 ()
P&D ID
PD018813
CAS
201943-63-7
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
This is the tritiated version of , but the tritium position is unspecified.
(GtoPdb)
DESCRIPTION
LY341495 is an antagonist of metabotropic glutamate (mGlu) receptors, with highest potency at the group II mGlu2, 3 and 8 receptors .
(GtoPdb)
DESCRIPTION
Highly potent, selective ETA antagonist
(Tocris Bioactive Compound Library)
DESCRIPTION
Very selective nanomolar potent antagonist for group II mGlu receptors. Also a relatively potent antagonist for group III mGlu receptors at high nanomolar to low micromolar concentrations. Kd values for human receptors are 1.67 (mGlu2), 0.75 (mGlu3), 31.6 (mGlu6), 72.7 (mGlu7a) and 14 nM (mGlu8a). IC50 values are 7.8, 8.2 and 22 μM for mGlu1a, mGlu5a and mGlu4 receptors, respectively. Readily brain penetrant and active in vivo.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
9
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
MedChem Express Bioactive Compound Library
Other bioactive compounds
Tocris Bioactive Compound Library
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
23
Molecular Weight
353.13
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
3
Rotatable Bonds
5
Ring Count
4
Aromatic Ring Count
2
cLogP
2.82
TPSA
109.85
Fraction CSP3
0.3
Chiral centers
3.0
Largest ring
6.0
QED
0.76
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
Glutamate (Metabotropic) Group II Receptors
MOA
Antagonist
Pathway
GPCR/G protein
Neuronal Signaling
Target
mGluR
Source data
