General
Preferred name
Myristicin
Synonyms
Myristicine ()
ELEMICIN ()
P&D ID
PD018765
CAS
607-91-0
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Myristicine is an orally bioavailable serotonin receptor antagonist and weak monoamine oxidase (MAO) inhibitor. Myristicine also exerts anti-cancer effects on gastric cancer cells by inhibiting the EGFR/ERK signaling pathway. Myristicine is the main component of nutmeg essential oil and has anti-cancer, anti-proliferative, antibacterial, anti-inflammatory and apoptosis-inducing effects. Myristicine abuse can produce hallucinogenic effects, organ damage, etc[1][2][3][4].
PRICE 29
DESCRIPTION Myristicin (Myristicine) is a natural product found in spices and umbelliferous plants. Myristicin has anti-cholinergic, Antibacterial, and hepatoprotective effects, it also has anti-inflammatory properties related with its inhibition of NO, cytokines,chemokines, and growth factors in dsRNA-stimulated macrophages via the calcium pathway. Myristicin can induce Apoptosis as characterised by alterations in the mitochondrial membrane potential, cytochrome c release, Caspase-3 activation, PARP-cleavage and DNA fragmentation. (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
0
Compound Sets
5
Cayman Chemical Bioactives
15201
Ki Database
Myristicin
MedChem Express Bioactive Compound Library
HY-N2510
Selleckchem Bioactive Compound Library
myristicin
TargetMol Bioactive Compound Library
T9113
External IDs
26
Properties
(calculated by RDKit )
Molecular Weight
192.08
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
1
cLogP
2.15
TPSA
27.69
Fraction CSP3
0.27
Chiral centers
0.0
Largest ring
6.0
QED
0.69
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
5-HT Receptor
Anti-infection
Bcl-2
Caspase
CYP17
GABA Receptor
IL Receptor
NO
PARP
Bacterial
EGFR
ERK
MAO,P450 (e.g. CYP17)
Pathway
Apoptosis
Chromatin/Epigenetic
DNA Damage/DNA Repair
GPCR/G protein
Immunology/Inflammation
Membrane Transporter/Ion Channel
Metabolism
Microbiology/virology
Neuroscience
Proteases/Proteasome
JAK/STAT Signaling
MAPK/ERK Pathway
Neuronal Signaling
Protein Tyrosine Kinase/RTK
Stem Cell/Wnt
Source data