General
Preferred name
TAUROLIDINE
Synonyms
Taurolin, Tauroline, Tauroflex ()
Taurolidina ()
Cyclo-taurolidine ()
Taurolidine component of taurolock ()
Taurolidine component of defencath ()
(cyclo)-taurolidine ()
W-3100M ()
P&D ID
PD018663
CAS
19388-87-5
Tags
available
drug
Drug Status
investigational
approved
Max Phase
4.0
Drug indication
infection
First approval
2023
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Taurolidine is a potent antimicrobial and anticancer agent. Taurolidine inhibits cell proliferation. Taurolidine induces apoptosis and autophagy. Taurolidine rescues mice from sepsis-associated lethality[1][2].
DESCRIPTION
Taurolidine is a thiadiazinane antimicrobial compound used to reduce the incidence of catheter-related bloodstream infections .
(GtoPdb)
DESCRIPTION
Taurolidine is a synthetic taurine analog with antimicrobial and anti-neoplastic actions. It displays broad bactericidal and fungicidal activity.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
15
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
Guide to Pharmacology
MedChem Express Bioactive Compound Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
39
Molecular Weight
284.06
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
0
cLogP
-2.67
TPSA
98.82
Fraction CSP3
1.0
Chiral centers
0.0
Largest ring
6.0
QED
0.57
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
antibiotic
Apoptosis
Bacterial
Autophagy
Antibiotics,Bacterial
Indication
catheter-related bloodstream infection
MOA
apoptosis stimulant
Pathway
Microbiology/virology
Anti-infection
Source data
