General
Preferred name
HARRINGTONINE
Synonyms
FH15975 ()
P&D ID
PD018525
CAS
26833-85-2
25302-09-4
Tags
available
nuisance
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Harringtonine is a natural Cephalotaxus alkaloid that inhibits protein synthesis. Harringtonine has anti-chikungunya virus (CHIKV) activities with an EC50 of 0.24 ¦ÌM.
PRICE 122
DESCRIPTION Harringtonine is a naturally occurring alkaloid that inhibits DNA synthesis and protein synthesis and strongly kills S-phase cells. Harringtonine has antitumor and antiviral activities. (TargetMol Bioactive Compound Library)
Cell lines
2
Organisms
0
Compound Sets
9
Cayman Chemical Bioactives
15361
Drug Repurposing Hub
Mcule NIBR MoA Box Subset
MCULE-3059804519
MedChem Express Bioactive Compound Library
HY-N0862
Novartis Chemogenetic Library (NIBR MoA Box)
Nuisance compounds in cellular assays
ReFrame library
Selleckchem Bioactive Compound Library
harringtonine
TargetMol Bioactive Compound Library
T8286
External IDs
25
Properties
(calculated by RDKit )
Molecular Weight
531.25
Hydrogen Bond Acceptors
10
Hydrogen Bond Donors
2
Rotatable Bonds
8
Ring Count
5
Aromatic Ring Count
1
cLogP
2.19
TPSA
123.99
Fraction CSP3
0.64
Chiral centers
4.0
Largest ring
7.0
QED
0.48
Structural alerts
1
Protein disruption
Translation inhibition
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Target
Influenza Virus
CHIKV
Antiviral
Member status
member
MOA
Translation Inititiation Inhibitor
protein synthesis inhibitor
Pathway
Anti-infection
Microbiology/virology
Source data