General
Preferred name
RHC 80267
Synonyms
U-57908 ()
RHC80267 ()
RHC-80267 ()
P&D ID
PD018358
CAS
83654-05-1
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
RHC80267 ia a diacylglycerol lipase (DAGL) inhibitor. It does not inhibit ABHD12.
(GtoPdb)
DESCRIPTION
Diacylglycerol lipase inhibitor
(Tocriscreen Plus)
DESCRIPTION
Inhibits Golgi-ER traffic; blocks exocytosis
(Tocris Bioactive Compound Library)
DESCRIPTION
Diacylglycerol lipase inhibitor
(Tocriscreen Total)
DESCRIPTION
RHC 80267 is a selective inhibitor of DAGL (IC50 values are 1.1 and 4 μM in rat cardiac myocytes and canine platelets respectively) that demonstrates relatively weak inhibition of phospholipases A2 and C. It potentiates acetylcholine evoked relaxation in mesenteric arteries by the inhibition of cholinesterase activity (IC50 = 4 μM).
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
12
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Drug Repurposing Hub
DrugMAP
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
23
Molecular Weight
394.26
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
9
Ring Count
2
Aromatic Ring Count
0
cLogP
4.64
TPSA
101.38
Fraction CSP3
0.8
Chiral centers
0.0
Largest ring
6.0
QED
0.34
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Cell Biology
Pathway
Immunology/Inflammation
Neuroscience
GPCR/G protein
Metabolic Enzyme/Protease
Neuronal Signaling
Target
COX
phosphatidylcholine
DAGL
DAGLA, DAGLB
Acyltransferase
mAChR
Phospholipase
AChR,COX,Phospholipase (e.g. PLA)
Primary Target
Other Lipid Metabolism
MOA
Inhibitor
triacylglycerol lipase inhibitor
Source data
