General
Preferred name
ANANDAMIDE
Synonyms
(5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide ()
KDS 2000 ()
Arachidonoyl Ethanolamide ()
Arachidonoyl Ethanolamide-d4 ()
Arachidonoyl Ethanolamide MaxSpec® Standard ()
P&D ID
PD018236
CAS
94421-68-8
946524-40-9
Tags
drug candidate
natural product
available
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Anandamide is an endogenous cannabinoid neurotransmitter found in animal and human organs, especially in the brain. It activates the cannabinoid receptors CB1 and CB2. Anandamide is also known to be an endogenous activator of the TRPV1 cation channel , which is involved in regulation of body temperature and nociception.
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
3
Compound Sets
11
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugMAP
Guide to Pharmacology
JUMP-Target 1 Compound Set
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
44
Molecular Weight
347.28
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
16
Ring Count
0
Aromatic Ring Count
0
cLogP
5.24
TPSA
49.33
Fraction CSP3
0.59
Chiral centers
0.0
Largest ring
0.0
QED
0.3
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Cannabinoid Receptor
Endogenous Metabolite
CACNA1G, CACNA1H, CACNA1I, CNR1, CNR2, GLRA1, GPR18, GPR55, KCNA2, KCNK3, KCNK9, TRPM8, TRPV1
GPR55
Pathway
GPCR/G protein
Metabolic Enzyme/Protease
Neuronal Signaling
Member status
member
MOA
Cannabinoid CB1 Agonists
TRPV1 (Vanilloid VR1 Receptor) Agonists
K(V)4.3 Channel Blocker
Cannabinoid Receptor agonist
Source data
