General
Preferred name
CARIPORIDE
Synonyms
HOE-642 ()
HOE-642 (Free Base) ()
CARIPORIDE MESYLATE ()
Cariporida ()
Cariporide mesilate ()
HOE 642 ()
Cariporide methanesulfonate ()
HOE642 ()
CARIPORIDA ()
P&D ID
PD018167
CAS
159138-80-4
159138-73-5
159138-81-5
Tags
available
drug candidate
Drug indication
Angina pectoris
Drug Status
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Cariporide (HOE-642) is a selective Na+/H+ exchange inhibitor.
PRICE
41
DESCRIPTION
Aminoglycoside antibiotic
(Tocris Bioactive Compound Library)
DESCRIPTION
Cariporide (HOE-642) (HOE-642), an effective NHE1 inhibitor, has inhibitory effects on the degranulation of human platelets, the formation of platelet-leukocyte-aggregates, and the activation of the GPIIb/IIIa receptor (PAC-1).
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
16
Cayman Chemical Bioactives
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugMAP
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
EUbOPEN Chemogenomics Library
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
39
Molecular Weight
283.1
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
3
Rotatable Bonds
3
Ring Count
1
Aromatic Ring Count
1
cLogP
0.84
TPSA
113.11
Fraction CSP3
0.33
Chiral centers
0.0
Largest ring
6.0
QED
0.56
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
NHE1
Sodium Channel
SLC9A1
Na+/H+ Exchanger (NHE)
Primary Target
Na+/H+ Exchanger
MOA
Inhibitor
Na+/H+ Exchanger type 1 (NHE-1) Inhibitors
sodium/hydrogen exchanger inhibitor
Member status
member
Pathway
Membrane Transporter/Ion Channel
Recommended Cell Concentration
None
Source data
