General
Preferred name
PD018141
Synonyms
2-Oleoylglycerol ()
2-oleoyl glycerol ()
P&D ID
PD018141
CAS
3443-84-3
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 110
DESCRIPTION 2-Oleoylglycerol is a lipid found in palm kernel, sunflower seed and rice bran.2-Oleoylglycerol acts as a GPR119 agonist with neuroprotective effects and induces secretion of glucagon-like peptide 1 (GLP-1).2-Oleoylglycerol is used in the modelling of non-alcoholic steatohepatitis.
DESCRIPTION 2-Oleoyl glycerol (2-OG) is a natural monoacylglycerol with an 18:1 oleoyl group at the sn-2 position of glycerol. 2-OG, like 2-arachidonoyl glycerol, is metabolized by monoacylglycerol lipase, but, unlike 2-AG, it is not metabolized by cyclooxygenases or lipoxygenases. (BOC Sciences Bioactive Compounds)
Compound Sets
12
BOC Sciences Bioactive Compounds
2-oleoyl-glycerol-cas-3443-84-3-18007
Cayman Chemical Bioactives
16537
Concise Guide to Pharmacology 2017/18
5112
Concise Guide to Pharmacology 2019/20
5112
Concise Guide to Pharmacology 2021/22
5112
Concise Guide to Pharmacology 2023/24
5112
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
DM5PXQU
Guide to Pharmacology
5112
JUMP-Target 1 Compound Set
5319879
ReFrame library
External IDs
37
Properties
(calculated by RDKit )
Molecular Weight
356.29
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
18
Ring Count
0
Aromatic Ring Count
0
cLogP
4.92
TPSA
66.76
Fraction CSP3
0.86
Chiral centers
0.0
Largest ring
0.0
QED
0.21
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
GPR119
MOA
glucose dependent insulinotropic receptor ligand
Solubility
Soluble in Chloroform (Slightly), Ethyl Acetate (Slightly)
Source data