General
Preferred name
OGT 2115
Synonyms
P&D ID
PD017814
CAS
853929-59-6
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION OGT 2115 is a potent, cell-permeable and orally active heparanase inhibitor with an IC50 of 0.4 ¦ÌM. OGT 2115 has anti-angiogenic properties (IC50 of 1 ¦ÌM). OGT 2115 also inhibits heparan sulfate degradation activity[1][2].
PRICE 123
DESCRIPTION OGT 2115 is an inhibitor of heparanase (IC50 = 0.4 ??M), an enzyme that cleaves heparan sulfate into glucuronic acid (GlcUA) and N-acetylglucosamine (GlcNAc). OGT 2115 also showed antiangiogenic properties (IC50=1 ??M).
DESCRIPTION OGT 2115 is a heparanase inhibitor with IC50 value of 0.4 μM. It shows antiangiogenic properties in vitro. (BOC Sciences Bioactive Compounds)
DESCRIPTION OGT 2115 is an inhibitor of heparanase (IC50 = 0.4 µM), an enzyme that cleaves heparan sulfate into glucuronic acid (GlcUA) and N-acetylglucosamine (GlcNAc). OGT 2115 also showed antiangiogenic properties (IC50=1 μM). (TargetMol Bioactive Compound Library)
DESCRIPTION Specific inhibitor of NF-kappaB activation (Tocris Bioactive Compound Library)
Compound Sets
6
BOC Sciences Bioactive Compounds
ogt-2115-cas-853929-59-6-item-129579
Cayman Chemical Bioactives
17324
CZ-OPENSCREEN Bioactive Library
MedChem Express Bioactive Compound Library
HY-100898
TargetMol Bioactive Compound Library
T16380
Tocris Bioactive Compound Library
2710
External IDs
12
Properties
(calculated by RDKit )
Molecular Weight
494.03
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
4
cLogP
5.68
TPSA
92.43
Fraction CSP3
0.04
Chiral centers
0.0
Largest ring
6.0
QED
0.34
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Heparanase
Glycosidase
Primary Target
Antiangiogenics
Pathway
Metabolic Enzyme/Protease
Source data