General
Preferred name
SU5614
Synonyms
SU-5614 ()
(Z)-SU5614 ()
Chloro-SU5416, Chloro-Semaxanib ()
AC1NS4RE ()
SU 5614 ()
P&D ID
PD017779
CAS
1055412-47-9
Tags
available
drug candidate
Drug indication
Airway inflammation
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
(Z)-SU5614 is a potent FLT3 inhibitor and selectively induces growth arrest, apoptosis, and cell cycle arrest in Ba/F3 and AML cell lines expressing a constitutively activated FLT3[1].
PRICE
56
DESCRIPTION
(Z)-SU5614 is a FLT3 inhibitor and selectively induces growth arrest, apoptosis, and cell cycle arrest in Ba/F3 and AML cell lines expressing a constitutively activated FLT3.
(Enamine Bioactive Compounds)
DESCRIPTION
It is a tyrosine kinase inhibitor.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
8
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
15
Molecular Weight
272.07
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
3
Aromatic Ring Count
2
cLogP
3.78
TPSA
44.89
Fraction CSP3
0.13
Chiral centers
0.0
Largest ring
6.0
QED
0.76
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
tyrosine kinase
Apoptosis
FLT3
Apoptosis related,c-Kit,FLT3,VEGFR
Pathway
Protein Tyrosine Kinase/RTK
Proteases/Proteasome
Source data
