General
Preferred name
CP-640186
Synonyms
CP 640186 HCl ()
CP-640,186 ()
CP 640186 ()
CP-640186 (hydrochloride) ()
CP640186 HCl ()
CP-640186 hydrochloride ()
CP 640,186 ()
P&D ID
PD017727
CAS
591778-68-6
591778-70-0
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION CP-640186 hydrochloride is an orally active and cell-permeable Acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively. Acetyl-CoA carboxylase (ACC) is a key enzyme of fatty acid metabolism that enables the synthesis of malonyl-CoA. CP-640186 hydrochloride can also stimulate muscle fatty acid oxidation[1][2].
PRICE 120
DESCRIPTION CP-640186 is an acetyl-CoA carboxylase (ACC) inhibitor , that binds to the enzyme's carboxyltransferase (CT) domain . It is active in vitro and in in vivo models . (GtoPdb)
DESCRIPTION CP-640186 is an orally active and cell-permeable Acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively. Acetyl-CoA carboxylase (ACC) is a key enzyme of fatty acid metabolism that enables the synthesis of malonyl-CoA. CP-640186 can also stimulate muscle fatty acid oxidation[1][2].
PRICE 115
DESCRIPTION CP-640186 is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively; with improved metabolic stability vs CP-610431. (BOC Sciences Bioactive Compounds)
DESCRIPTION CP-640186 is an orally active and cell-permeable Acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 34 nM and 550 nM ACC2 and ACC1 respectively. (Enamine Bioactive Compounds)
DESCRIPTION CP-640186 hydrochloride (CP 640186 HCl) is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor, including rat liver ACC1 (IC50: 53 nM) and rat skeletal muscle ACC2 (IC50: 61 nM); with higher metabolic stability than CP-610431. (TargetMol Bioactive Compound Library)
DESCRIPTION CP-640186 is an isozyme-nonselective Acetyl-CoA carboxylase (ACCase) inhibitor. The IC50s of CP-640186(CP 640186) is 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively. (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
1
Compound Sets
12
AdooQ Bioactive Compound Library
A13134
BOC Sciences Bioactive Compounds
cp640186-hcl-cas-591778-70-0-item-84-462271
Cayman Chemical Bioactives
17691
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
DMO0PS9
Enamine Bioactive Compounds
EBC-118036
EU-OPENSCREEN Bioactive Compound Library
EOS100228
Guide to Pharmacology
12243
MedChem Express Bioactive Compound Library
HY-15259A
HY-15259
Selleckchem Bioactive Compound Library
cp-640186
TargetMol Bioactive Compound Library
T3622
T1889
External IDs
33
Properties
(calculated by RDKit )
Molecular Weight
485.27
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
3
Ring Count
6
Aromatic Ring Count
3
cLogP
4.17
TPSA
53.09
Fraction CSP3
0.47
Chiral centers
1.0
Largest ring
6.0
QED
0.52
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
ACC
ACC1
ACC2
ACACA, ACACB
acetyl-CoA carboxylase
MOA
acetyl-CoA carboxylase inhibitor
Pathway
Metabolism
Metabolic Enzyme/Protease
Source data