General
Preferred name
OG-L002
Synonyms
OGL002 ()
OG-L002 hydrochloride ()
P&D ID
PD017720
CAS
1357302-64-7
1357300-15-2
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
OG-L002 is a potent and selective inhibitor of the histone demethylase, lysine (K)-specific demethylase 1A (KDM1A aka LSD1).
(GtoPdb)
DESCRIPTION
OG-L002 is a potent and highly selective LSD1 inhibitor with an IC50 of 0.02 ¦ÌM. OG-L002 is a potent monoamine oxidases (MAO) inhibitor with IC50s of 1.38 ¦ÌM and 0.72 ¦ÌM for MAO-A and MAO-B, respectively. OG-L002 potently inhibits the expression of HSV IE genes[1].
PRICE
75
DESCRIPTION
Potent TGF-betaRI inhibitor; orally bioavailable
(Tocris Bioactive Compound Library)
DESCRIPTION
OG-L002 potently inhibits HSV IE gene expression in both HeLa and HFF cells with IC50s of ~10 μM and ~3 μM, respectively. OG-L002 is a potent and highly selective inhibitor of LSD1 (IC50 = 0.02 μM), and is a potent inhibitor of monoamine oxidases (MAO) with IC50s of 1.38 and 0.72 μM for MAO-A and MAO-B, respectively.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
OG-L002 is an effective and selective LSD1 inhibitor (IC50: 20 nM), showing 69- and 36-fold selectivity over MAO-A and MAO-B, respectively.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
11
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Drug Repurposing Hub
DrugMAP
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
30
Molecular Weight
225.12
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
2
cLogP
2.87
TPSA
46.25
Fraction CSP3
0.2
Chiral centers
2.0
Largest ring
6.0
QED
0.83
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Chromatin/Epigenetic
Microbiology/virology
Neuroscience
Anti-infection
Epigenetics
Neuronal Signaling
Primary Target
Histone Demethylases
MOA
Inhibitor
histone lysine demethylase inhibitor
Target
KDM1A
LSD1 inhibitor
Histone Demethylase,LSD1
Histone Demethylase
HSV
Monoamine Oxidase
LSD1
Solubility
Soluble in DMSO, Ethanol
Source data
