General
Preferred name
aurora kinase inhibitor II
Synonyms
IUN-70219 ()
quinazoline deriv. 1 ()
Aurora kinase inhibitor-2 ()
ANILINOQUINAZOLINE1 ()
P&D ID
PD017710
CAS
331770-21-9
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Aurora kinase inhibitor-2 is a selective and ATP-competitive Aurora kinase inhibitor with IC50s of 310 nM and 240 nM for Aurora A and Aurora B, respectively[1].
PRICE 193
DESCRIPTION The Aurora kinases are a family of serine/threonine kinases that are key regulators of mitosis and cytokinesis. Aurora kinase inhibitor II is a cell-permeable anilinoquinazoline that blocks the activity of Aurora A with IC50 of 0.39 µM. This compound has the ability to permeate the cell and is involved in the regulation of the cell cycle, particularly cell division. This compound has the ability to permeate the cell and is involved in the regulation of the cell cycle, particularly cell division. (BOC Sciences Bioactive Compounds)
DESCRIPTION Aurora kinase inhibitor-2 (IUN-70219) is a cell-permeable anilinoquinazoline that inhibit the activity of Aurora A (IC50 = 0.39 M). (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
0
Compound Sets
8
BOC Sciences Bioactive Compounds
aurora-kinase-inhibitor-ii-cas-331770-21-9-item-163459
Cayman Chemical Bioactives
17541
DrugMAP
DMJDU5S
Guide to Pharmacology
5930
MedChem Express Bioactive Compound Library
HY-112355
Selleckchem Bioactive Compound Library
aurora-kinase-inhibitor-ii
TargetMol Bioactive Compound Library
T9040
ZINC Tool Compounds
ZINC000000590935
External IDs
15
Properties
(calculated by RDKit )
Molecular Weight
400.15
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
4
cLogP
4.64
TPSA
85.37
Fraction CSP3
0.09
Chiral centers
0.0
Largest ring
6.0
QED
0.49
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Aurora A
Aurora Kinase
Pathway
Cell Cycle/Checkpoint
Chromatin/Epigenetic
Cell Cycle/DNA Damage
Epigenetics
Source data