General
Preferred name
GSK137647A
Synonyms
GSK 137647 ()
GSK 137647A ()
GSK-37647 ()
P&D ID
PD017596
CAS
349085-82-1
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION GSK137647A (GSK 137647) is a potent, selective free fatty acid receptor 4 (FFA4) agonist with pEC50 values of 6.3, 6.2, and 6.1 for human, mouse and rat FFA4, and pEC50 values < 4.5 for all three species for FFA1, FFA2, and FFA3, respectively. GSK137647A has anti-inflammatory activity. GSK137647A induces insulin secretion and inhibits epithelial ion transport, GSK137647A is related to regulation of glucose homeostasis and anti-inflammatory response[1][2].
PRICE 53
DESCRIPTION High affinity and selective Smoothened (Smo) receptor antagonist (Tocris Bioactive Compound Library)
DESCRIPTION Potent and selective FFA4 (GPR120) agonist (Tocriscreen Plus)
DESCRIPTION GSK137647A (GSK 137647) is a selective agonist of FFA4. (TargetMol Bioactive Compound Library)
Compound Sets
12
AdooQ Bioactive Compound Library
A14542
Axon Medchem Screening Library
2582
Cayman Chemical Bioactives
17712
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
JUMP-Target 1 Compound Set
743974
MedChem Express Bioactive Compound Library
HY-19995
Selleckchem Bioactive Compound Library
gsk137647a
TargetMol Bioactive Compound Library
T3171
Tocris Bioactive Compound Library
5257
Tocriscreen Plus
5257
VGSC-DB
NA0145
External IDs
14
Properties
(calculated by RDKit )
Molecular Weight
305.11
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
2
Aromatic Ring Count
2
cLogP
3.42
TPSA
55.4
Fraction CSP3
0.25
Chiral centers
0.0
Largest ring
6.0
QED
0.94
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Target
GPR120
FFAR4
FFA4/GPR120 agonist
Free Fatty Acid Receptor
GPR
Primary Target
Free Fatty Acid Receptors
MOA
Agonist
free fatty acid receptor agonist
VGSC Target
Nav1.5
Pathway
GPCR/G protein
Endocrinology/Hormones
Source data