General
Preferred name
beta-Asarone
Synonyms
Cis-Isoasarone ()
CIS-ASARONE ()
Cis-Isoelemicin ()
.beta.-Asarone ()
P&D ID
PD017561
CAS
5273-86-9
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Beta-asarone is an orally active and BBB-penatrable anti-inflammatory agent and neuroprotective agent, which is the major ingredient of Acorus tatarinowii Schott. Beta-asarone can protect nerve cells from apoptosis and autophagy, inhibit expression of ¦Á-synuclein, as well as myocardial protection. Beta-asarone can be used in the study of neurological and cardiovascular diseases[1][2][3][4].
PRICE 56
DESCRIPTION 1. beta-Asarone (Cis-Isoelemicin) may be a potential preventive drug for Alzheimer's disease. 2. Beta-Asarone prevents autophagy and synaptic loss by reducing ROCK expression in SAMP8 mice. 3. The co-administration of beta-Asarone(Cis-Isoasarone) and l-dopa may contribute to the treatment of 6-OHDA-induced damage in rats by inhibiting autophagy activity. 4. Beta-Asarone exhibits anti-inflammatory effects by suppressing the production of pro-inflammatory mediators through NF-??B signaling and the JNK pathways in activated microglial cells and might be developed as a promising candidate to treat various neuroinflammatory diseases.
DESCRIPTION 1. beta-Asarone (Cis-Isoelemicin) may be a potential preventive drug for Alzheimer's disease. 2. Beta-Asarone prevents autophagy and synaptic loss by reducing ROCK expression in SAMP8 mice. 3. The co-administration of beta-Asarone(Cis-Isoasarone) and l-dopa may contribute to the treatment of 6-OHDA-induced damage in rats by inhibiting autophagy activity. 4. Beta-Asarone exhibits anti-inflammatory effects by suppressing the production of pro-inflammatory mediators through NF-κB signaling and the JNK pathways in activated microglial cells and might be developed as a promising candidate to treat various neuroinflammatory diseases. (TargetMol Bioactive Compound Library)
Compound Sets
4
Cayman Chemical Bioactives
11682
MedChem Express Bioactive Compound Library
HY-N1501
Selleckchem Bioactive Compound Library
beta-asarone
TargetMol Bioactive Compound Library
T4S1962
External IDs
20
Properties
(calculated by RDKit )
Molecular Weight
208.11
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
4
Ring Count
1
Aromatic Ring Count
1
cLogP
2.75
TPSA
27.69
Fraction CSP3
0.33
Chiral centers
0.0
Largest ring
6.0
QED
0.76
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
JNK
NF-κB
NF-¦ÊB
α-synuclein
¦Á-synuclein
Pathway
NF-¦ªb
MAPK
Neuronal Signaling
Source data