General
Preferred name
PYRIDOSTATIN
Synonyms
RR82 ()
Pyridostatin Trihydrochloride(free base 1085412-37-8 ) ()
RR-82 Trihydrochloride ()
Pyridostatin pentahydrochloride ()
RR-82 hydrochloride ()
Pyridostatin (TFA) ()
Pyridostatin (hydrochloride) ()
RR82 (TFA) ()
RR82 (hydrochloride) ()
Pyridostatin (RR82) Trifluoroacetate Salt ()
Pyridostatin TFA ()
Pyridostatin Trihydrochloride ()
P&D ID
PD017545
CAS
1781882-65-2
1085412-37-8
1472611-44-1
2517456-88-9
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Pyridostatin (RR82) is a G-quadruplex DNA stabilizing agent (Kd=490 nM) and can target DNA and RNA G4s in cells. Pyridostatin promotes growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage. Pyridostatin targets the proto-oncogene Src. Pyridostatin reduced SRC protein levels and SRC-dependent cellular motility in human breast cancer cells[1][2].
PRICE 124
DESCRIPTION Pyridostatin (RR82) is a synthetic small-molecule stabilizer of G-quadruplexes, a secondary structure of DNA that usually exists in the end of the chromosome or the telomeres.
PRICE 137
DESCRIPTION Pyridostatin is a G-quadruplex-interacting drug which can promote growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage. (BOC Sciences Bioactive Compounds)
DESCRIPTION Secreted Frizzled-related protein-1 (sFRP-1) inhibitor; increases Wnt signaling (Tocris Bioactive Compound Library)
DESCRIPTION Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes including c-kit, K-ras and Bcl-2. (TargetMol Bioactive Compound Library)
DESCRIPTION Pyridostatin Trihydrochloride (RR-82 Trihydrochloride) is a G-quadruplexe stabilizer, with a Kd of 490 nM. (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
3
Compound Sets
7
AdooQ Bioactive Compound Library
A12717
BOC Sciences Bioactive Compounds
pyridostatin-cas-1085412-37-8-item-84-456822
MedChem Express Bioactive Compound Library
HY-15176A
HY-15176B
Other bioactive compounds
Selleckchem Bioactive Compound Library
pyridostatin-trifluoroacetate-salt
TargetMol Bioactive Compound Library
T4470
T4457
Tocris Bioactive Compound Library
4763
External IDs
33
Properties
(calculated by RDKit )
Molecular Weight
596.25
Hydrogen Bond Acceptors
11
Hydrogen Bond Donors
5
Rotatable Bonds
13
Ring Count
5
Aromatic Ring Count
5
cLogP
2.7
TPSA
202.62
Fraction CSP3
0.19
Chiral centers
0.0
Largest ring
6.0
QED
0.13
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
G-quadruplex
Pathway
Cell Cycle/DNA Damage
Cell Cycle/Checkpoint
DNA Damage/DNA Repair
Primary Target
Cell Cycle Inhibitors
MOA
DNA/RNA Synthesis modulator
Source data