General
Preferred name
CGP 35348
Synonyms
CGP-35348 ()
CGP35348 ()
P&D ID
PD017402
CAS
123690-79-9
Tags
available
drug candidate
Drug indication
Epilepsy
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 91
DESCRIPTION CGP 35348 is a selective antagonist of GABAB receptor (EC50 = 34 ??M). CGP 35348 can be used in studies of neuromuscular coordination and spatial learning after neonatal brain damage in albino mice.
DESCRIPTION CGP 35348 is a selective and brain penetrant GABAB receptor antagonist (IC50 = 34 μM as measured in rat cortical membranes) with higher affinity for postsynaptic than presynaptic receptors. (BOC Sciences Bioactive Compounds)
DESCRIPTION CGP 35348 is a selective antagonist of GABAB receptor (EC50 = 34 μM). CGP 35348 can be used in studies of neuromuscular coordination and spatial learning after neonatal brain damage in albino mice. (TargetMol Bioactive Compound Library)
DESCRIPTION Potent and selective GABAB antagonist (Tocris Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
12
BOC Sciences Bioactive Compounds
cgp-35348-cas-123690-79-9-360418
Cayman Chemical Bioactives
18599
Concise Guide to Pharmacology 2017/18
1069
Concise Guide to Pharmacology 2019/20
1069
Concise Guide to Pharmacology 2021/22
1069
Concise Guide to Pharmacology 2023/24
1069
DrugMAP
DMZM70X
Guide to Pharmacology
1069
MedChem Express Bioactive Compound Library
HY-103530
ReFrame library
TargetMol Bioactive Compound Library
T21793
Tocris Bioactive Compound Library
1245
External IDs
21
Properties
(calculated by RDKit )
Molecular Weight
225.11
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
8
Ring Count
0
Aromatic Ring Count
0
cLogP
0.96
TPSA
81.78
Fraction CSP3
1.0
Chiral centers
1.0
Largest ring
0.0
QED
0.47
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
GABAB
GABA Receptor
Primary Target
GABAB Receptors
MOA
Antagonist
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Neuroscience
Source data