General
Preferred name
FOSTAMATINIB DISODIUM
Synonyms
R-935788 Sodium ()
R-788 Sodium ()
R788(Disodium) ()
R788 (disodium hexahydrate) ()
R788 (Fostamatinib) Disodium ()
Tamatinib Fosdium ()
R788 Disodium ()
R788(Disodium)R788 (Fostamatinib) Disodium ()
R935788 ()
Fostamatinib disodium hexahydrate ()
Fostamatinib (disodium hexahydrate) ()
Fostamatinib sodium ()
Fostamatinib (R788) disodium ()
Tavalisse, R788 disodium hexahydrate, Tamatinib Fosdium hexahydrate ()
R-788 SODIUM HYDRATE ()
Fostamatinib disodium salt hexahydrate ()
R935788 SODIUM ()
R935788 SODIUM HYDRATE ()
Tavlesse ()
Tavalisse ()
R-935788 SODIUM HYDRATE ()
Fostamatinib sodium hydrate ()
R788 SODIUM HYDRATE ()
R788 SODIUM ()
R788 (sodium salt) ()
P&D ID
PD017221
CAS
1025687-58-4
914295-16-2
Tags
available
drug
prodrug
drug candidate
Drug indication
Thrombocytopenia
Drug Status
approved
Max Phase
4.0
First approval
2018
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION R788 (Fostamatinib) disodium, a prodrug of the active metabolite R406, is a Syk inhibitor with IC50 of 41 nM, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. Phase 3. (BOC Sciences Bioactive Compounds)
Cell lines
1
Organisms
0
Compound Sets
11
AdooQ Bioactive Compound Library
A21873
A10771
BOC Sciences Bioactive Compounds
fostamatinib-sodium-cas-1025687-58-4-item-84-286685
Cayman Chemical Bioactives
18501
ChEMBL Approved Drugs
CHEMBL3989516
ChEMBL Drugs
CHEMBL3989516
DrugMAP
DM3274D
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL2105644
LSP-OptimalKinase library (Laboratory of Systems Pharmacology)
CHEMBL2105644
MedChem Express Bioactive Compound Library
HY-13038B
HY-13038
Selleckchem Bioactive Compound Library
fostamatinib-disodium-hexahydrate
R788(Fostamatinib-disodium)
TargetMol Bioactive Compound Library
T2605
External IDs
32
Properties
(calculated by RDKit )
Molecular Weight
624.11
Hydrogen Bond Acceptors
14
Hydrogen Bond Donors
2
Rotatable Bonds
10
Ring Count
4
Aromatic Ring Count
3
cLogP
-4.16
TPSA
192.38
Fraction CSP3
0.3
Chiral centers
0.0
Largest ring
6.0
QED
0.16
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Angiogenesis
Tyrosine Kinase/Adaptors
Protein Tyrosine Kinase/RTK
Target
SYK
FLT3
Source data