General
Preferred name
TELAVANCIN
Synonyms
Vibativ ()
TELAVANCIN HYDROCHLORIDE ()
Sib-1533A ()
Telavancin HCl ()
Televancin ()
Televancin hydrochloride ()
TD-6424 ()
P&D ID
PD017217
CAS
372151-71-8
560130-42-9
Tags
natural product
drug
available
Approved by
FDA
First approval
2009
Drug Status
approved
withdrawn
Drug indication
Discovery agent
Staphylococcus infection
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Telavancin is a glycopeptide antibacterial drug that is derived from vancomycin . It is used to treat Gram-positive infections, including MRSA.
(GtoPdb)
ABSORPTION
Telavancin demonstrates linear pharmacokinetics at doses between 1 and 12.5 mg/kg. Furthermore, 24 hours post-infusion of a dose of 7.5 to 15 mg/kg, activity against MRSA and penicillin-resistant Streptococcus pneumonia can still be observed. The trough concentration at this point of time is approximately 10; μg/mL. Telavancin also has poor bioavailability and must be administered over 30-120 minutes IV. ; Cmax, healthy subjects, 10 mg/kg = 93.6 ± 14.2 μg/mL;; AUC (0- â), healthy subjects, 10 mg/kg = 747 ± 129 μg · h/mL;; AUC (0-24h), healthy subjects, 10 mg/kg = 666± 107 μg · h/mL;; Time to steady state = 3 days;
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
13
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP Approved Drugs
Guide to Pharmacology
Natural product-based probes and drugs
NCATS Inxight Approved Drugs
ReFrame library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
37
Molecular Weight
1753.64
Hydrogen Bond Acceptors
28
Hydrogen Bond Donors
23
Rotatable Bonds
30
Ring Count
12
Aromatic Ring Count
5
cLogP
2.69
TPSA
598.09
Fraction CSP3
0.53
Chiral centers
18.0
Largest ring
16.0
QED
0.02
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Biosynthetic Origin
Peptide (NRPS), Carbohydrate (Aminoglycoside)
Therapeutic Indication
Antibacterial
Therapeutic Class
Antimicrobial
Source data
