General
Preferred name
Gardiquimod
Synonyms
Gardiquimod (diTFA) ()
P&D ID
PD017187
CAS
1020412-43-4
1159840-61-5
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Gardiquimod is an imidazoline TLR7/8 agonist. Gardiquimod inhibits HIV-1 infection of macrophages and activated peripheral blood mononuclear cells (PBMCs). Gardiquimod specifically activates TLR7 at concentrations below 10 ¦ÌM.
PRICE 79
DESCRIPTION Gardiquimod could inhibit HIV-1 infection of macrophages and activated peripheral blood mononuclear cells. Gardiquimod is an imidazoquinoline analog and is a TLR7/8 agonist. When used at concentrations below 10???M, Gardiquimod specifically activates TLR7.
DESCRIPTION Gardiquimod diTFA is an imidazoline TLR7/8 agonist. Gardiquimod diTFA inhibits HIV-1 infection of macrophages and activated peripheral blood mononuclear cells (PBMCs). Gardiquimod diTFA specifically activates TLR7 at concentrations below 10 ¦ÌM.
DESCRIPTION Gardiquimod could inhibit HIV-1 infection of macrophages and activated peripheral blood mononuclear cells. Gardiquimod is an imidazoquinoline analog and is a TLR7/8 agonist. When used at concentrations below 10 μM, Gardiquimod specifically activates TLR7. (TargetMol Bioactive Compound Library)
Compound Sets
3
Cayman Chemical Bioactives
18877
MedChem Express Bioactive Compound Library
HY-103697
HY-103697A
TargetMol Bioactive Compound Library
T15371
External IDs
24
Properties
(calculated by RDKit )
Molecular Weight
313.19
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
3
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
3
cLogP
2.05
TPSA
88.99
Fraction CSP3
0.41
Chiral centers
0.0
Largest ring
6.0
QED
0.67
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
HIV-1
TLR7
TLR8
Toll-like Receptor (TLR)
Pathway
Immunology/Inflammation
Microbiology/virology
Proteases/Proteasome
Source data