General
Preferred name
(Rac)-WAY-161503
Synonyms
WAY 161503 hydrochloride ()
WAY-161503 ()
P&D ID
PD017117
CAS
276695-22-8
75704-24-4
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION (Rac)-WAY-161503 is a potent, selective, highly affinity 5-HT2C receptor agonist with a Ki of 4 nM and an EC50 of 12 nM. (Rac)-WAY-161503 displays higher affinity for 5-HT2C than 5-HT2A and 5-HT2B receptors. (Rac)-WAY-161503 has anti-obesity and antidepressant effects[1][2].
PRICE 88
DESCRIPTION WAY-161503 is a full agonist of 5-HT2C receptors that exhiits ~6-fold less potent at 5-HT2A receptors (Ki = 18 nM) and 20-fold less potent at 5-HT2B receptors (Ki = 60 nM). (BOC Sciences Bioactive Compounds)
DESCRIPTION (Rac)-WAY-161503 is a selective and high-affinity agonist of the 5-HT2C receptor [Ki: 4 nM; EC50: 12 nM], exhibiting anti-obesity and antidepressant effects. (TargetMol Bioactive Compound Library)
DESCRIPTION Potent, selective LTD4 /LTE4 receptor antagonist (Tocris Bioactive Compound Library)
DESCRIPTION Potent, selective 5-HT2C agonist (Tocriscreen Total)
DESCRIPTION WAY 161503 hydrochloride is a potent and selective 5-HT2C receptor agonist (Ki = 4 nM; EC50 = 12 nM). (BOC Sciences Bioactive Compounds)
Compound Sets
6
BOC Sciences Bioactive Compounds
way-161503-cas-75704-24-4-32328
way-161503-hydrochloride-cas-276695-22-8-368655
Cayman Chemical Bioactives
17269
MedChem Express Bioactive Compound Library
HY-103138A
TargetMol Bioactive Compound Library
T13332
Tocris Bioactive Compound Library
1801
Tocriscreen Total
External IDs
23
Properties
(calculated by RDKit )
Molecular Weight
271.03
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
0
Ring Count
3
Aromatic Ring Count
1
cLogP
1.72
TPSA
44.37
Fraction CSP3
0.36
Chiral centers
1.0
Largest ring
6.0
QED
0.76
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
5-HT2C
5-HT Receptor
Primary Target
5-HT2C Receptors
MOA
Agonist
Pathway
GPCR/G protein
Neuronal Signaling
Neuroscience
Source data