General
Preferred name
TCN 201
Synonyms
TCN-201 ()
TCN201 ()
P&D ID
PD017016
CAS
852918-02-6
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
TCN-201 is compound 1 in . TCN-201 is a potent negative allosteric modulator of glycine but not glutamate at GluN2A NMDA receptors .
(GtoPdb)
PRICE
92
DESCRIPTION
TCN 201 is a selective antagonist of NMDA receptors containing the NR2A subunit.
DESCRIPTION
NMDA antagonist; selective for GluN2A over GluN2B containing receptors
(Tocris Bioactive Compound Library)
DESCRIPTION
Selective NR1/NR2A receptor antagonist
(Tocriscreen Plus)
DESCRIPTION
TCN 201 is an NMDA receptor antagonist with selectivity for NR1/NR2A over NR1/NR2B-containing receptors (pIC50 = 6.8 and <4.3, respectively, in human recombinant NR1/NR2A and NR1/NR2B FLIPR/Ca2+ assays).
(BOC Sciences Bioactive Compounds)
DESCRIPTION
TCN-201 is a potent, selective and non-competitive antagonist of NMDA receptors containing the NR2A subunit. TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner.
(Enamine Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
17
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
Enamine Bioactive Compounds
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EUbOPEN Chemogenomics Library
Guide to Pharmacology
JUMP-Target 1 Compound Set
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
16
Molecular Weight
461.06
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
3
Rotatable Bonds
6
Ring Count
3
Aromatic Ring Count
3
cLogP
3.03
TPSA
104.37
Fraction CSP3
0.05
Chiral centers
0.0
Largest ring
6.0
QED
0.49
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Ion Channels
Primary Target
NMDA Receptors
MOA
Antagonist
glutamate receptor antagonist
Target
GRIN2A
NR2A antagonist
iGluR
NMDAR
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Recommended Cell Concentration
10 uM
Source data
