General
Preferred name
T 98475
Synonyms
T-98475 ()
P&D ID
PD016926
CAS
192887-28-8
199119-18-1
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
T 98475 is a potent, orally active and non-peptide gonadotropin-releasing hormone (GnRH, LHRH) receptor antagonist (IC50 = 0.2, 4.0 and 60 nM for human, monkey and rat GnRH receptors, respectively). T 98475 inhibits LH release in vitro (IC50 = 100 nM) and reduces plasma LH concentration in castrated male cynomolgus monkeys.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
7
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
CZ-OPENSCREEN Bioactive Library
DrugMAP
Guide to Pharmacology
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
19
Molecular Weight
657.25
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
1
Rotatable Bonds
11
Ring Count
5
Aromatic Ring Count
5
cLogP
7.85
TPSA
80.64
Fraction CSP3
0.27
Chiral centers
0.0
Largest ring
6.0
QED
0.15
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Member status
member
MOA
GnRH (LHRH) Antagonists
Target
GnRH antagonist
Source data
