General
Preferred name
S 14506
Synonyms
S 14506 hydrochloride ()
S-14506 ()
S-14506 (hydrochloride) ()
P&D ID
PD016878
CAS
135721-98-1
135722-25-7
286369-38-8
Tags
available
drug candidate
Drug indication
Anxiety disorder
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
S-14506 hydrochloride is a potent 5-HT1A agonist, as well as 5-HT2A/2C antagonist. S-14506 hydrochloride displays dopamine antagonist properties by blocking dopamine D2 receptors. S-14506 hydrochloride inhibits the in vivo binding of [3H]raclopride in striatum and olfactory bulbs. S-14506 hydrochloride has the potential for the research of anxiolytic agent[1][2][3].
PRICE
133
DESCRIPTION
Highly potent 5-HT1A agonist; displays unique binding mechanism
(Tocriscreen Plus)
DESCRIPTION
Highly potent 5-HT1A agonist; displays unique binding mechanism
(Tocriscreen Total)
DESCRIPTION
S 14506 hydrochloride is a highly potent and selective 5-HT1A receptor full agonist (pKi = 9.0, 6.6, 7.5, 6.6 and < 6.0 for 5-HT1A, 5-HT1B, 5-HT1C, 5-HT2 and 5-HT3 receptors, respectively). S 14506 possibly binds between the agonist binding site and the G protein interaction switch site. S 14506 exhibits anxiolytic and antihypertensive properties.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
S 14506 hydrochloride is a 5-HT1A receptor full agonist.
(TargetMol Bioactive Compound Library)
DESCRIPTION
S 14506 is a potent and selective 5-HT1A agonist.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
11
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
Guide to Pharmacology
MedChem Express Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
36
Molecular Weight
407.2
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
3
cLogP
3.54
TPSA
44.81
Fraction CSP3
0.29
Chiral centers
0.0
Largest ring
6.0
QED
0.68
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Target
5-HT1A
HTR1A
5-HT1A agonist
5-HT Receptor
Dopamine Receptor
MOA
serotonin receptor agonist
Pathway
GPCR/G protein
Neuronal Signaling
Neuroscience
Source data
