General
Preferred name
Ro 60-0175 fumarate
Synonyms
Ro 60-0175 ()
Ro60-0175 (fumarate) ()
P&D ID
PD016856
CAS
169675-09-6
169675-08-5
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Ro60-0175 fumarate is a potent and selective agonist of 5-HT2C receptor[1].
DESCRIPTION
Ro 60-0175 fumarate is a potent and selective SR-2 agonist. It is a potent, selective 5-HT2 receptor agonist, with selectivity for the 5-HT2C subtype (pKi= 9, 7.5, 5.4, 5.2 and 5.6 for human 5-HT2C, 2A, 1A, 6 and 7 receptors respectively).
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Potent, selective 5-HT2C agonist
(Tocriscreen Plus)
DESCRIPTION
Potent, selective 5-HT2C agonist
(Tocriscreen Total)
DESCRIPTION
Selective 5-HT1A agonist
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
8
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
EUbOPEN Chemogenomics Library
MedChem Express Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
11
Molecular Weight
342.08
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
3
Rotatable Bonds
4
Ring Count
2
Aromatic Ring Count
2
cLogP
2.49
TPSA
105.55
Fraction CSP3
0.2
Chiral centers
1.0
Largest ring
6.0
QED
0.74
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Primary Target
5-HT2C Receptors
MOA
Agonist
Target
5-HT2C agonist
5-HT Receptor
Pathway
GPCR/G protein
Neuronal Signaling
Recommended Cell Concentration
100 nM
Source data
