General
Preferred name
JWH 018
Synonyms
JWH 018 (exempt preparation) ()
JWH 018-d9 ()
JWH-018 ()
JWH 018-d9 (CRM) ()
JWH 018 (CRM) ()
P&D ID
PD016807
CAS
209414-07-3
1415744-44-3
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
JWH-018 is a synthetic cannabinoid. It is the non-fluorinated analogue of .
DESCRIPTION
JWH-018 is a synthetic cannabinoid generated in the 1990s with limited selectivity between CB1 and CB2 receptors (original synthesis reported in: https://www.sciencedirect.com/science/article/pii/S0960894X01801554). In vivo, it displays the 'classical tetrad' activity of CB1 agonists, with analgesic, hypothermic, hypolocomotive and cataleptic properties . In the UK, it was the structural basis for definition of a series of compounds classified as Controlled Drugs under the Misuse of Drugs Act 1971 (Amendment) Order 2016 (see: https://www.legislation.gov.uk/ukdsi/2016/9780111148716). It is the non-fluorinated analogue of .
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
3
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
20
Molecular Weight
341.18
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
4
cLogP
6.22
TPSA
22.0
Fraction CSP3
0.21
Chiral centers
0.0
Largest ring
6.0
QED
0.3
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
CB2 agonist
Source data
