General
Preferred name
SCH 58261
Synonyms
CHEMBL17127 ()
SCH-58261 ()
SCH58261 ()
PF-1913539 ()
[3H]SCH 58261 ()
P&D ID
PD016768
CAS
160098-96-4
Tags
available
probe
drug candidate
Drug indication
Alzheimer disease
Probe info
Probe type
P&D approved
calculated probe
Probe selectivity
protein-selective
Probe sources
Tool Compound Set
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
7
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
SCH 58261 is a potent, selective and competitive antagonist of adenosine A2A receptor with an IC50 of 15 nM, and displays 323-, 53- and 100-fold more selective for A2A receptor than A1, A2B, and A3 receptors, respectively[1][2][3].
PRICE
96
DESCRIPTION
Leukotriene receptor antagonist
(Tocris Bioactive Compound Library)
DESCRIPTION
Potent, highly selective A2A antagonist
(Tocriscreen Plus)
DESCRIPTION
Potent, highly selective A2A antagonist
(Tocriscreen Total)
DESCRIPTION
SCH 58261 is a potent and selective A2a adenosine receptor antagonist.The Ki =2.3 nM for rat A2a and 2 nM is for bovine A2a.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
14
Axon Medchem Screening Library
Cayman Chemical Bioactives
Drug Repurposing Hub
DrugMAP
DrugMatrix
Ki Database
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
Tool Compound Set
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
27
Molecular Weight
345.13
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
5
Aromatic Ring Count
5
cLogP
2.56
TPSA
100.06
Fraction CSP3
0.11
Chiral centers
0.0
Largest ring
6.0
QED
0.54
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Target
Adenosine A2a receptor
ADORA1, ADORA2A, ADORA2B, ADORA3
A2A antagonist
Adenosine Receptor
A2A (bovine)
A2A (rat)
Primary Target
Adenosine A2A Receptors
MOA
Antagonist
Adenosine Receptor antagonist
Pathway
GPCR/G protein
Neuroscience
Source data
