General
Preferred name
SR 142948
Synonyms
2-[5-(2,6-DIMETHOXYPHENYL)-1-[4-[N-[3-(DIMETHYLAMINO)PROPYL]-N-METHYLCARBAMOYL]-2-ISOPROPYLPHENYL]PYRAZOL-3-YLCARBOXAMIDO]ADAMANTANE-2-CARBOXYLIC ACID ()
SR142948A ()
SR 142948 (dihydrochloride) ()
P&D ID
PD016767
CAS
184162-64-9
184162-21-8
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Selective, orally active vasopressin V1A receptor antagonist
(Tocris Bioactive Compound Library)
DESCRIPTION
SR142948A is an antagonist of non-peptide neurotensin (NT) receptor with a high affinity (IC50 = 0.32 - 3.96 nM; Ki < 10 nM). SR142948A has the effect of inhibiting bile acid secretion and some stimulant drugs.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
9
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
DrugMAP
DrugMatrix
EUbOPEN Chemogenomics Library
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
15
Molecular Weight
685.38
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
2
Rotatable Bonds
13
Ring Count
7
Aromatic Ring Count
3
cLogP
5.71
TPSA
126.23
Fraction CSP3
0.54
Chiral centers
0.0
Largest ring
6.0
QED
0.23
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
Neurotensin Receptors
MOA
Antagonist
NTSR1 antagonist
NTSR2 antagonist
Neurotensin Antagonists
Member status
member
Target
NT antagonist
Neurotensin Receptor
Pathway
GPCR/G protein
Neuronal Signaling
Solubility
Soluble to 75 mM in DMSO and to 25 mM in water
Source data
