General
Preferred name
Chromanol 293B
Synonyms
(-)-[3R,4S]-Chromanol 293B ()
(3R,4S)-293B ()
(3R,4S)-293B ()
P&D ID
PD016759
CAS
163163-24-4
163163-23-3
Tags
drug candidate
available
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
(3R,4S)-293B acts as an antagonist of the KCNQ1 potassium channel (Kv7.1). The stereo-specific effects of the (3R,4S)-293B and enantiomers has been reported by Seebohm et al. (2001) . Note that some biological activity data may have been generated using the racemic mixture (chromanol 239B) represented by the 'flat' structure with PubChem CID 656731. Additional partially specified stereo-isomers include CID 44275282 and CID 44275281.
(GtoPdb)
DESCRIPTION
Chromanol 293B is a selective blocker of the slow delayed rectifier K+ current (IKs) with IC50 of 1-10 ¦ÌM and a weak inhibitor of KATP channel. Chromanol 293B also blocks the CFTR chloride current with an IC50 of 19 ¦ÌM[1].
DESCRIPTION
Potent and selective NMDA antagonist; acts at glycine site
(Tocris Bioactive Compound Library)
DESCRIPTION
IKs blocker. Enantiomer of Chromanol 293B (Cat. No. 1412)
(Tocriscreen Total)
DESCRIPTION
(-)-[3R,4S]-Chromanol 293B is one of the chromanols, which inhibits cAMP-mediated Cl- secretion in colon crypts by a blockade of a cAMP-activated K+ conductance. It selectively inhibits the slow component of delayed rectifier K+ current. It has negligible inhibitory action at KV11.1 (hERG) channels. It may be a useful research chemical.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
9
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Drug Repurposing Hub
DrugMAP
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
24
Molecular Weight
324.11
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
1
cLogP
1.41
TPSA
90.63
Fraction CSP3
0.53
Chiral centers
2.0
Largest ring
6.0
QED
0.91
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
Voltage-gated Potassium (KV) Channels
MOA
Blocker
potassium channel blocker
Target
KCNQ blocker
CFTR
Potassium Channel
Pathway
Membrane Transporter/Ion Channel
Source data
