General
Preferred name
JNJ-10191584
Synonyms
JNJ 10191584 maleate ()
JNJ 10191584 ()
P&D ID
PD016756
CAS
869497-75-6
73903-17-0
Tags
available
drug candidate
biased GPCR ligand
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
JNJ-10191584 is a selective, orally active antagonist of the histamine H4 receptor .
(GtoPdb)
DESCRIPTION
Potent and selective sst2 agonist
(Tocris Bioactive Compound Library)
DESCRIPTION
Selective H4 receptor antagonist; orally active
(Tocriscreen Plus)
DESCRIPTION
Selective H4 receptor antagonist; orally active
(Tocriscreen Total)
DESCRIPTION
The maleate salt form of JNJ 10191584, which has been found to be a selective histamine H4 receptor silent antagonist and could restrain mast cell and eosinophil chemotaxis in vitro.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
JNJ-10191584 is a selective histamine H4 receptor antagonist. It inhibits mast cell in vitro with IC50 value of 138nM. JNJ-10191584 has antiinflammatory and analgesic effects in animal studies of acute inflammation. No development was reported for the treatment of Allergic rhinitis, Atopic dermatitis, Pruritus and Respiratory tract disorders.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
10
Axon Medchem Screening Library
BiasDB
BOC Sciences Bioactive Compounds
Drug Repurposing Hub
DrugMAP
Guide to Pharmacology
ReFrame library
Tocris Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
27
Molecular Weight
278.09
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
3
Aromatic Ring Count
2
cLogP
1.6
TPSA
52.23
Fraction CSP3
0.38
Chiral centers
0.0
Largest ring
6.0
QED
0.86
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Primary Target
Histamine H4 Receptors
MOA
Antagonist
Histamine Receptor antagonist
Target
HRH4
H4 antagonist
Solubility
Solubility in DMSO: ~ 19 mg/ml (or 68 mM)
Source data
