General
Preferred name
EBIO
Synonyms
1-EBIO ()
1-ethyl-1H-benzo[d]imidazol-2(3H)-one ()
1-Ethyl-2-benzimidazolinone ()
1-Ethylbenzimidazolinone, 1-Ethyl-2-benzimidazolinone ()
P&D ID
PD016751
CAS
10045-45-1
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
1-EBIO is an activator of Ca2+ sensitive K+ channels. 1-EBIO is used to study the role of K+ channels in diverse physiological functions[1].
PRICE
29
DESCRIPTION
Potent AMPA antagonist; more water soluble form of NBQX (Cat. No. 0373)
(Tocris Bioactive Compound Library)
DESCRIPTION
Activator of epithelial KCa channels
(Tocriscreen Plus)
DESCRIPTION
Activator of epithelial KCa channels
(Tocriscreen Total)
DESCRIPTION
1-EBIO is an activator of epithelial KCa channels, and it stimulates a large and sustained trans-epithelial Cl- secretory response across T84 monolayers. 1-EBIO induces hyperpolarization to the same magnitude as ACh in aortic value endothelial cells. It also activates cAMP-sensitive K+ channel in mouse colonic epithelia.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
1-EBIO (1-EBIO) is a calium channel agonist.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
25
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
IPPI - DB
JUMP-Target 1 Compound Set
Ki Database
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
26
Molecular Weight
162.08
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
2
Aromatic Ring Count
2
cLogP
1.35
TPSA
37.79
Fraction CSP3
0.22
Chiral centers
0.0
Largest ring
6.0
QED
0.67
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Ion Channels
Target
Calcium Channel
KCNN1, KCNN2, KCNN3, KCNN4
K+ channel opener
KCNN1
Potassium Channel
Primary Target
Calcium-Activated Potassium (KCa) Channels
MOA
Activator
SK2 Potassium Channel Activators
Potassium Channel activator
Member status
member
Pathway
Membrane Transporter/Ion Channel
Metabolism
Source data
