General
Preferred name
LUZINDOLE
Synonyms
N-0774 ()
P&D ID
PD016731
CAS
117946-91-5
Tags
available
probe
drug candidate
Drug indication
Sleep-wake disorder
Probe info
Probe type
P&D approved
calculated probe
Probe selectivity
protein-selective
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Orthogonal probes
10
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Luzindole (N-0774) is a selective melatonin receptor antagonist. Luzindole preferentially targets MT2 (Mel1b) over MT1 (Mel1a) with Ki values of 10.2 and 158 nM for human MT2 and MT1, respectively. Luzindole suppresses experimental autoimmune encephalomyelitis (EAE), and exerts antidepressant-like activity[1][2][3].
PRICE
164
DESCRIPTION
Competitive melatonin MT1/MT2 antagonist
(Tocriscreen Plus)
DESCRIPTION
Competitive melatonin MT1/MT2 antagonist
(Tocriscreen Total)
DESCRIPTION
Luzindole is a melatonin receptor antagonist which preferentially targets MT1B.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Luzindole (N-0774) is a selective melatonin receptor antagonist that inhibits experimental autoimmune encephalomyelitis and exhibits antidepressant-like activity. It preferentially targets MT2 (Mel1b) over MT1 (Mel1a), with Ki values of 10.2 nM for human MT2 and 158 nM for MT1.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
0
Compound Sets
20
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
DrugMatrix
EUbOPEN Chemogenomics Library
Guide to Pharmacology
High-quality chemical probes
Ki Database
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
Probe Miner (suitable probes)
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
23
Molecular Weight
292.16
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
3
cLogP
3.44
TPSA
44.89
Fraction CSP3
0.21
Chiral centers
0.0
Largest ring
6.0
QED
0.74
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Target
Melatonin Receptor
MT1 receptor
MT2 receptor
MTNR1A, MTNR1B
Melatonin antagonist
MT Receptor
Member status
member
MOA
Melatonin MT2 Antagonists
melatonin receptor antagonist
Pathway
GPCR/G protein
Neuronal Signaling
Neuroscience
Recommended Cell Concentration
1 uM
Source data
