General
Preferred name
SNC 80
Synonyms
SNC-80 ()
SNC80 ()
NIH 10815 ()
SNC 80 ()
P&D ID
PD016712
CAS
156727-74-1
Tags
drug candidate
biased GPCR ligand
available
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 113
DESCRIPTION SNC 80 (NIH 10815) is a potent, highly selective and non-peptide ??-opioid receptor agonist, Ki = 1.78 nM, IC50 = 2.73 nM. SNC80 also selectively activates ??-?? heteromer in HEK293 cells with an EC50 of 52.8 nM. SNC80 shows antinociceptive, antihyperalgesic and antidepressant?like effects. SNC80 has the potential for multiple headache disorders treatment.
DESCRIPTION Highly selective non-peptide δ agonist (Tocriscreen Total)
DESCRIPTION Highly selective non-peptide delta agonist (Tocriscreen Plus)
DESCRIPTION Potent kappa agonist (Tocris Bioactive Compound Library)
DESCRIPTION SNC 80 is a potent and non-peptide δ-opioid agonist, displaying 2000-fold selectivity over μ-opioid receptors. SNC 80 exhibits antinociceptive as well as pro-convulsant effects in vivo. (BOC Sciences Bioactive Compounds)
DESCRIPTION SNC 80 (NIH 10815) is a potent, highly selective and non-peptide δ-opioid receptor agonist, Ki = 1.78 nM, IC50 = 2.73 nM. SNC80 also selectively activates μ-δ heteromer in HEK293 cells with an EC50 of 52.8 nM. SNC80 shows antinociceptive, antihyperalgesic and antidepressant‐like effects. SNC80 has the potential for multiple headache disorders treatment. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
4
Compound Sets
19
Axon Medchem Screening Library
1412
BiasDB
SNC-80
BOC Sciences Bioactive Compounds
snc-80-cas-156727-74-1-item-196720
Cayman Chemical Bioactives
15599
Concise Guide to Pharmacology 2017/18
1611
Concise Guide to Pharmacology 2019/20
1611
Concise Guide to Pharmacology 2021/22
1611
Concise Guide to Pharmacology 2023/24
1611
Drug Repurposing Hub
DrugMAP
DMJI5H0
Guide to Pharmacology
1611
Mcule NIBR MoA Box Subset
MCULE-3504495920
MedChem Express Bioactive Compound Library
HY-101202
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
TargetMol Bioactive Compound Library
T8414
Tocris Bioactive Compound Library
0764
Tocriscreen Plus
0764
Tocriscreen Total
External IDs
23
Properties
(calculated by RDKit )
Molecular Weight
449.3
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
9
Ring Count
3
Aromatic Ring Count
2
cLogP
4.85
TPSA
36.02
Fraction CSP3
0.46
Chiral centers
3.0
Largest ring
6.0
QED
0.51
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Target
δ-opioid receptor
OPRD1
d-opioid agonist
Opioid Receptor
Primary Target
? Opioid Receptors
MOA
Agonist
delta-Opioid Agonists
Member status
member
Pathway
GPCR/G protein
Neuronal Signaling
Endocrinology/Hormones
Neuroscience
Source data