General
Preferred name
SNC 80
Synonyms
SNC80 ()
SNC-80 ()
NIH 10815 ()
SNC 80 ()
P&D ID
PD016712
CAS
156727-74-1
Tags
drug candidate
natural product
biased GPCR ligand
available
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Highly selective non-peptide delta agonist (Tocriscreen Plus)
DESCRIPTION Potent kappa agonist (Tocris Bioactive Compound Library)
DESCRIPTION Highly selective non-peptide δ agonist (Tocriscreen Total)
DESCRIPTION SNC 80 is a potent and non-peptide δ-opioid agonist, displaying 2000-fold selectivity over μ-opioid receptors. SNC 80 exhibits antinociceptive as well as pro-convulsant effects in vivo. (BOC Sciences Bioactive Compounds)
Cell lines
0
Organisms
4
Compound Sets
18
Axon Medchem Screening Library
1412
BiasDB
SNC-80
BOC Sciences Bioactive Compounds
snc-80-cas-156727-74-1-item-196720
Cayman Chemical Bioactives
15599
Concise Guide to Pharmacology 2017/18
1611
Concise Guide to Pharmacology 2019/20
1611
Concise Guide to Pharmacology 2021/22
1611
Concise Guide to Pharmacology 2023/24
1611
Drug Repurposing Hub
DrugMAP
DMJI5H0
Guide to Pharmacology
1611
Mcule NIBR MoA Box Subset
MCULE-3504495920
MedChem Express Bioactive Compound Library
HY-101202
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Tocris Bioactive Compound Library
0764
Tocriscreen Plus
0764
Tocriscreen Total
External IDs
21
Properties
(calculated by RDKit )
Molecular Weight
449.3
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
9
Ring Count
3
Aromatic Ring Count
2
cLogP
4.85
TPSA
36.02
Fraction CSP3
0.46
Chiral centers
3.0
Largest ring
6.0
QED
0.51
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Primary Target
? Opioid Receptors
MOA
Agonist
delta-Opioid Agonists
Member status
member
Target
OPRD1
d-opioid agonist
Opioid Receptor
Pathway
GPCR/G protein
Neuronal Signaling
Source data