General
Preferred name
GW 803430
Synonyms
GW803430 ()
GW-803430 ()
GW-3430 ()
P&D ID
PD016670
CAS
515141-51-2
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION GPR35 agonist (Tocris Bioactive Compound Library)
DESCRIPTION GW 803430 is a potent and selective melanin-concentrating hormone receptor 1 (MCH1) antagonist (IC50 = 9.3 nM). GW 803430 exhibits antiobesity and antidepressant-like effects in rats and mice. (BOC Sciences Bioactive Compounds)
Compound Sets
14
Axon Medchem Screening Library
1569
BOC Sciences Bioactive Compounds
gw-803430-cas-515141-51-2-item-272135
Cayman Chemical Bioactives
13948
Concise Guide to Pharmacology 2017/18
4033
Concise Guide to Pharmacology 2019/20
4033
Concise Guide to Pharmacology 2021/22
4033
Concise Guide to Pharmacology 2023/24
4033
Drug Repurposing Hub
DrugMAP
DMWAEJ3
Guide to Pharmacology
4033
MedChem Express Bioactive Compound Library
HY-11083
ReFrame library
Tocris Bioactive Compound Library
4242
ZINC Tool Compounds
ZINC000003815899
External IDs
18
Properties
(calculated by RDKit )
Molecular Weight
481.12
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
0
Rotatable Bonds
7
Ring Count
5
Aromatic Ring Count
4
cLogP
5.25
TPSA
56.59
Fraction CSP3
0.28
Chiral centers
0.0
Largest ring
6.0
QED
0.36
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Primary Target
Melanin-concentrating Hormone Receptors
MOA
Antagonist
melanin inhibitor
Target
KCNH2, MCHR1
MCH1 antagonist
MCHR1 (GPR24)
Pathway
GPCR/G protein
Neuronal Signaling
Source data