General
Preferred name
TALTOBULIN
Synonyms
HTI 286 ()
Taltobulin (hydrochloride) ()
HTI-286 ()
SPA-110 ()
HTI-286 hydrochloride ()
SPA-110 hydrochloride ()
Taltobulin trifluoroacetate ()
Taltobulin (trifluoroacetate) ()
Taltobulina ()
Taltobuline ()
P&D ID
PD016647
CAS
228266-40-8
228266-41-9
Tags
available
drug candidate
nuisance
Drug indication
Solid tumour/cancer
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Taltobulin (HTI-286), a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Taltobulin inhibits the polymerization of purified tubulin, disrupts microtubule organization in cells, and induces mitotic arrest, as well as apoptosis[1].
DESCRIPTION Taltobulin hydrochloride (HTI-286 hydrochloride), a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Taltobulin hydrochloride inhibits the polymerization of purified tubulin, disrupts microtubule organization in cells, and induces mitotic arrest, as well as apoptosis[1].
DESCRIPTION Taltobulin, also known as HTI-286 and SPA-110, is a fully synthetic analog of the natural tripeptide hemiasterlin, inhibits tubulin polymerization and circumvents transport-based resistance to taxanes. HTI-286 was a potent inhibitor of proliferation (mean IC50 = 2.5 ± 2.1 nm in 18 human tumor cell lines) and had substantially less interaction with multidrug resistance protein (P-glycoprotein) than currently used antimicrotubule agents, including paclitaxel, docetaxel, vinorelbine, or vinblastine. (BOC Sciences Bioactive Compounds)
DESCRIPTION Taltobulin trifluoroacetate is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Taltobulin trifluoroacetate inhibits the polymerization of purified tubulin, disrupts microtubule organization in cells, and induces mitotic arrest, as well as apoptosis. (BOC Sciences Bioactive Compounds)
Cell lines
7
Organisms
0
Compound Sets
11
Axon Medchem Screening Library
1650
BOC Sciences Bioactive Compounds
taltobulin-cas-228266-40-8-87959
taltobulin-trifluoroacetate-cas-228266-41-9-463599
Cayman Chemical Bioactives
32852
ChEMBL Drugs
CHEMBL182319
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
DM1ZYCA
EU-OPENSCREEN Bioactive Compound Library
EOS100492
MedChem Express Bioactive Compound Library
HY-15584
HY-15584B
Nuisance compounds in cellular assays
ReFrame library
External IDs
34
Properties
(calculated by RDKit )
Molecular Weight
473.33
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
3
Rotatable Bonds
10
Ring Count
1
Aromatic Ring Count
1
cLogP
3.6
TPSA
98.74
Fraction CSP3
0.59
Chiral centers
3.0
Largest ring
6.0
QED
0.45
Structural alerts
1
Tubulin modulation
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
MOA
tubulin polymerization inhibitor
Target
Tubulin inhibitor
ADC Payload
Apoptosis
Microtubule/Tubulin
ADC Cytotoxin
Pathway
Antibody-drug Conjugate/ADC Related
Cell Cycle/DNA Damage
cytoskeleton
Solubility
Soluble in DMSO, not in water
Source data