General
Preferred name
(S)-(-)-BAY K 8644
Synonyms
(-)-BAY-R-5417 ()
(-)-BAY-K-8644 ()
(-)-(S)-BayK8644 ()
(S)-(-)-Bay-K-8644 ()
S(-)-BAY K 8644 ()
(S)-(?)-BAY-K-8644 ()
P&D ID
PD016590
CAS
98625-26-4
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Allosteric modulator of GABAA receptors
(Tocris Bioactive Compound Library)
DESCRIPTION
Ca2+-channel activator (L-type)
(Tocriscreen Total)
DESCRIPTION
S(-)-BAY K 8644 is an activator of voltage-sensitive L-type calcium channels with positive inotropic, vasoconstrictive and behavioral effects in vivo. It is the enantiomer of (±)-Bay K 8644. It increased whole-cell Ca2+ currents in A7r5 smooth muscle cells but effectively blocked further stimulatio. It enhanced transcoronary exchange more markedly than (+/-)-Bay W 5035 or (+/-)-Bay T 5006, reflecting the differences in coronary constrictor activity. It demonstrates vasoconstrictive and positive inotropic effects in vivo as well as behavioral effects, including deficits to motor function. It can enable reprogramming of mouse embryonic fibroblasts after transduction with Oct4/Klf when combined with BIX01294.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
13
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugMAP
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
18
Molecular Weight
356.1
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
1
cLogP
3.35
TPSA
81.47
Fraction CSP3
0.31
Chiral centers
1.0
Largest ring
6.0
QED
0.51
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
CaV1.x Channels (L-type)
MOA
Activator
L-type calcium channel activator
Target
CACNA1C
Calcium (Ca2+) channel activator
Calcium Channel
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Solubility
10 mM in DMSO
Source data
