General
Preferred name
PF-04447943
Synonyms
PF 04447943 ()
Edelinontrine ()
PF04447943 ()
PF-4447943 ()
CRD740 ()
PF4447943 ()
Edelinontrina ()
Crd-740 ()
CRD-740 ()
EDELINONTRINA ()
P&D ID
PD016564
CAS
1082744-20-4
Tags
available
drug candidate
Drug indication
Alzheimer disease
Sickle-cell disorder
Drug Status
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Edelinontrine (PF-04447943) is a potent inhibitor of human recombinant PDE9A (IC50=12 nM) with >78-fold selectivity, respectively, over other PDE family members (IC50>1000 nM).
PRICE
96
DESCRIPTION
PF-04447943 is a brain-permeable phosphodiesterase inhibitor that is selective for PDE9A (IC50 = 12 nM) over other PDEs.
(Enamine Bioactive Compounds)
DESCRIPTION
PF-04447943 (Edelinontrine) is a potent and selective phosphodiesterase 9A inhibitor with an IC50 of 12 nM, which is 78-fold more selective than that used for other PDE family members (IC50>1000 nM).PF-04447943 exhibits anti-inflammatory activity, attenuates inflammatory responses by inhibiting oxidative stress, inflammation, and modulating T-cell polarization, and may be useful for research on sickle cell anemia.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
13
Axon Medchem Screening Library
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugMAP
Enamine Bioactive Compounds
EUbOPEN Chemogenomics Library
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
25
Molecular Weight
395.21
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
5
Aromatic Ring Count
3
cLogP
1.5
TPSA
101.82
Fraction CSP3
0.55
Chiral centers
2.0
Largest ring
6.0
QED
0.71
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
PDE9A
PDE9A inhibitor
Phosphodiesterase (PDE)
Member status
member
MOA
PDE9A gene inhibitor
phosphodiesterase inhibitor
Pathway
Metabolism
Metabolic Enzyme/Protease
Recommended Cell Concentration
None
Source data
