General
Preferred name
GSK2256294
Synonyms
GSK 2256294 ()
GSK 2256294A ()
GSK2256294A ()
GSK-2256294A ()
GSK-2256294 ()
P&D ID
PD016537
CAS
1142090-23-0
Tags
available
drug candidate
Drug indication
Chronic obstructive pulmonary disease
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION GSK2256294A (GSK 2256294) is a selective and orally active inhibitor of soluble epoxide hydrolase (sEH). GSK2256294A inhibits recombinant human sEH, rat sEH orthologs and murine sEH orthologs with IC50s of 27, 61 and 189 pM, respectively. GSK2256294A can be used for the research of chronic obstructive pulmonary disease (COPD) and cardiovascular disease[1].
PRICE 319
DESCRIPTION GSK2256294 is an epoxide hydrolase 2 (sEH) inhibitor. (GtoPdb)
DESCRIPTION GSK2256294A (GSK 2256294) is potent, selective inhibitor of recombinant human, rat and mouse sEH with IC50 of 27 pM, 61 pM and 189 pM, respectively. (TargetMol Bioactive Compound Library)
Compound Sets
9
Axon Medchem Screening Library
2220
ChEMBL Drugs
CHEMBL3818875
Drug Repurposing Hub
DrugMAP
DM7FN12
EU-OPENSCREEN Bioactive Compound Library
EOS100455
Guide to Pharmacology
9718
MedChem Express Bioactive Compound Library
HY-19644
ReFrame library
TargetMol Bioactive Compound Library
T15430
External IDs
17
Properties
(calculated by RDKit )
Molecular Weight
447.2
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
3
Rotatable Bonds
6
Ring Count
3
Aromatic Ring Count
2
cLogP
3.4
TPSA
115.62
Fraction CSP3
0.48
Chiral centers
2.0
Largest ring
6.0
QED
0.62
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
sEH
EPHX2
sEH inhibitor
epoxide hydrolase
MOA
epoxide hydolase inhibitor
Pathway
Metabolism
Metabolic Enzyme/Protease
Source data