General
Preferred name
VIXOTRIGINE
Synonyms
Vixotrigine ()
CNV 1014802 ()
CNV-1014802 ()
GSK-1014802 ()
RAXATRIGINE ()
CNV1014802 ()
Vixotrigine (hydrochloride) ()
GSK-1014802 (hydrochloride) ()
CNV1014802 (hydrochloride) ()
Raxatrigine (GSK1014802) ()
CNV 1014802 hydrochloride ()
BIIB074 ()
Raxatrigine (hydrochloride) ()
GSK-1014802 hydrochloride ()
Vixotrigine hydrochloride ()
CNV1014802A ()
GSK-1014802A ()
GSK1014802A ()
CNV-1014802A ()
RAXATRIGINE HYDROCHLORIDE ()
Raxatrigine ()
Vixotrigina ()
BIIB-074 ()
GSK1014802 ()
P&D ID
PD016525
CAS
934240-30-9
934240-31-0
Tags
available
drug candidate
Drug indication
Trigeminal neuralgia
Bipolar disorder
Lumbosacral radiculopathy
Drug Status
investigational
Max Phase
3.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Vixotrigine (BIIB074) is a voltage-gated sodium channel (NaV) blocker that is in development for analgesic potential in conditions of neuropathic pain . It blocks peripheral and central nervous system NaV isoforms. Vixotrigine also has activity as a monoamine oxidase B (MAO-B) inhibitor (IC50 ~4 nM). (GtoPdb)
DESCRIPTION GSK-1014802 hydrochloride is the hydrochloride form of GSK-1014802, which is a novel analgesic for the treatment of lumbosacral radiculopathy (sciatica) and trigeminal neuralgia. It acts as a selective, small-molecule, state-dependent Nav1.7 voltage-gated sodium channel blocker. It received orphan-drug designation from the US Food and Drug Administration in July 2013. It was developed by Convergence Pharmaceuticals. It is currently in phase II studies in bipolar depression. (BOC Sciences Bioactive Compounds)
Compound Sets
13
AdooQ Bioactive Compound Library
A13020
Axon Medchem Screening Library
2548
1899
BOC Sciences Bioactive Compounds
gsk-1014802-hydrochloride-cas-934240-31-0-item-474127
Cayman Chemical Bioactives
23490
ChEMBL Drugs
CHEMBL3544912
CHEMBL3544913
Drug Repurposing Hub
DrugBank
DB11706
DrugMAP
DMLV1ET
Guide to Pharmacology
12645
MedChem Express Bioactive Compound Library
HY-12796A
HY-12796
ReFrame library
TargetMol Bioactive Compound Library
T2342
VGSC-DB
NA0448
NA0449
NA0450
NA0451
NA0452
NA0453
NA0454
External IDs
40
Properties
(calculated by RDKit )
Molecular Weight
314.14
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
2
cLogP
2.68
TPSA
64.35
Fraction CSP3
0.28
Chiral centers
2.0
Largest ring
6.0
QED
0.89
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Membrane Transporter/Ion Channel
Target
Sodium Channel
Na+ channel blocker
MOA
Sodium Channel blocker
VGSC Target
Nav1.1
Nav1.2
Nav1.3
Nav1.4
Nav1.5
Nav1.6
Nav1.8
Solubility
DMSO: ≥ 31 mg/Ml
Source data