General
Preferred name
SR 144528
Synonyms
SR144528 ()
2016-06-07: SR 144528 ()
SR 144528-d3 ()
P&D ID
PD016518
CAS
192703-06-3
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
SR144528 is a selective CB2 receptor antagonist with potential anti-inflammatory action.
(GtoPdb)
DESCRIPTION
SR144528 is a potent and selective CB2 receptor antagonist with a Ki of 0.6 nM.
PRICE
150
DESCRIPTION
SR144528 is an antagonist of the CB2 receptor (Ki = 0.6 nM) and inhibits microsomal ACAT activity (IC50 = 3.6 ??M).
DESCRIPTION
SR 144528 is a cannabinoid (CB) receptor 2 inverse agonist with selectivity for CB2 over CB1 receptors. It antagonizes the inhibitory effects of the cannabinoid receptor agonist CP 55,940 on forskolin-stimulated adenylyl cyclase activity in cell lines permanently expressing the h CB2 receptor. It selectively blocks the mitogen-activated protein kinase activity induced by CP 55,940 in cell lines expressing h CB2.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
SR144528 is an antagonist of the CB2 receptor (Ki = 0.6 nM) and inhibits microsomal ACAT activity (IC50 = 3.6 μM).
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
15
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
DrugMAP
EUbOPEN Chemogenomics Library
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
18
Molecular Weight
475.24
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
5
Aromatic Ring Count
3
cLogP
6.81
TPSA
46.92
Fraction CSP3
0.45
Chiral centers
3.0
Largest ring
6.0
QED
0.44
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
CB2
CB2 antagonist
Cannabinoid Receptor
Member status
member
MOA
Cannabinoid CB2 Inverse Agonists
ACAT Inhibitors
Pathway
GPCR/G protein
Neuronal Signaling
Recommended Cell Concentration
10 uM
Source data
