General
Preferred name
TROVAFLOXACIN MESYLATE
Synonyms
Trovafloxacin (mesylate) ()
Trovafloxacin methanesulfonate ()
CP-99219-27 ()
Trovan mesylate ()
Trovafloxacin mesilate ()
CP-99,219-27 ()
P&D ID
PD016442
CAS
147059-75-4
147059-72-1
Tags
available
drug
Drug Status
approved
withdrawn
Max Phase
4.0
First approval
1997
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Trovafloxacin mesylate is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive, Gram-negative and anaerobic organisms. Trovafloxacin mesylate blocks the DNA gyrase and topoisomerase IV activity. Trovafloxacin mesylate is also a potent, selective and orally active pannexin 1 channel (PANX1) inhibitor with an IC50 of 4 ¦ÌM for PANX1 inward current. Trovafloxacin mesylate does not inhibit connexin 43 gap junction or PANX2. Trovafloxacin mesylate leads to dysregulated fragmentation of apoptotic cells by inhibiting PANX1[1][2][3].
PRICE
123
DESCRIPTION
Trovafloxacin is a broad-spectrum fluoroquinolone antibiotic that inhibits the activity of DNA gyrase and topoisomerase IV, enzymes involved in DNA replication. It also acts as an effective and specific inhibitor of the pannexin 1 channel (PANX1, IC50 = 4 ??M).
DESCRIPTION
Trovafloxacin is a broad spectrum antibiotic. It is used to treat gonorrhea and chlamydia.
(Enamine Bioactive Compounds)
DESCRIPTION
Antibiotic; inhibits bacterial DNA synthesis
(Tocriscreen Plus)
DESCRIPTION
Trovafloxacin is a broad-spectrum fluoroquinolone antibiotic that inhibits the activity of DNA gyrase and topoisomerase IV, enzymes involved in DNA replication. It also acts as an effective and specific inhibitor of the pannexin 1 channel (PANX1, IC50 = 4 μM).
(TargetMol Bioactive Compound Library)
DESCRIPTION
Inducer of neuronal differentiation in MSCs
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
11
Axon Medchem Screening Library
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
Enamine Bioactive Compounds
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
17
Molecular Weight
512.1
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
3
Rotatable Bonds
3
Ring Count
5
Aromatic Ring Count
3
cLogP
1.4
TPSA
155.82
Fraction CSP3
0.29
Chiral centers
3.0
Largest ring
6.0
QED
0.44
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Cell Biology
Target
TRP Channel
panx1
Topo IV
Bacterial
DNA-gyrase
Topo IV inhibitor
antibiotic
Topoisomerase
Primary Target
DNA, RNA and Protein Synthesis
MOA
Inhibitor
Pathway
Anti-infection
Cell Cycle/DNA Damage
Cell Cycle/Checkpoint
DNA Damage/DNA Repair
Membrane Transporter/Ion Channel
Microbiology/virology
Source data
