General
Preferred name
TRAXOPRODIL
Synonyms
CP-101606-27 ()
CP101606 ()
CP 101606 mesylate ()
CP 101606 ()
CP-101,606 ()
TRAXOPRODIL MESYLATE ()
SU5403 ()
CP101,606 ()
CP 101,606 ()
CP-101606 ()
Traxoprodil mesilate trihydrate ()
Traxoprodil mesilate hydrate ()
CP-101,606-27 ()
Traxoprodil mesylate trihydrate ()
P&D ID
PD016412
CAS
134234-12-1
188591-67-5
189894-57-3
Tags
available
drug candidate
Drug indication
Discovery agent
Parkinson disease
Ischemic stroke
Stroke
Neurological disorder
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Traxoprodil (CP101,606) is a potent and selective NMDA antagonist and protect hippocampal neurons with an IC50 of 10 nM.
PRICE 52
DESCRIPTION CP 101606 is a potent and selective NR2B antagonist of N-Methyl-D-Aspartate (NMDA) glutamate receptors. It decreases pentylenetetrazol-induced seizures. (BOC Sciences Bioactive Compounds)
DESCRIPTION Traxoprodil (CP101606) is a selective NMDA antagonist and protects hippocampal neurons (IC50: 10 nM). (TargetMol Bioactive Compound Library)
DESCRIPTION Traxoprodil mesylate is a NR2B selective antagonist of NMDA glutamate receptors. (BOC Sciences Bioactive Compounds)
Cell lines
0
Organisms
1
Compound Sets
17
Axon Medchem Screening Library
2254
1406
BOC Sciences Bioactive Compounds
cp-101606-cas-134234-12-1-item-290149
traxoprodil-mesylate-cas-188591-67-5-item-55183
Cayman Chemical Bioactives
23884
ChEMBL Drugs
CHEMBL17350
CHEMBL3989673
Drug Repurposing Hub
DrugBank
DB18795
DrugMAP
DMIU19E
DM1ZQEN
DMV1408
Enamine Bioactive Compounds
EBC-756172
EU-OPENSCREEN Bioactive Compound Library
EOS100751
Guide to Pharmacology
4163
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL17350
Mcule NIBR MoA Box Subset
MCULE-7999494180
MedChem Express Bioactive Compound Library
HY-W018061
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
TargetMol Bioactive Compound Library
TQ0233
ZINC Tool Compounds
ZINC000000005936
External IDs
51
Properties
(calculated by RDKit )
Molecular Weight
327.18
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
3
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
2
cLogP
2.8
TPSA
63.93
Fraction CSP3
0.4
Chiral centers
2.0
Largest ring
6.0
QED
0.81
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Membrane Transporter/Ion Channel
Neuroscience
Neuronal Signaling
Member status
member
MOA
NR2B Antagonists
glutamate receptor antagonist
Target
GRIN2B
NR2B antagonist
iGluR
NMDA Receptor
Therapeutic Class
Analgesics
Source data