General
Preferred name
U-0126
Synonyms
U0126 ()
U0126 Ethanol ()
U0126-EtOH ()
U 0126 ()
P&D ID
PD016353
CAS
218601-62-8
109511-58-2
1173097-76-1
Tags
available
drug candidate
Drug indication
Discovery agent
Drug Status
investigational
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
U0126 (U0126-EtOH) is a potent, non-ATP competitive and selective MEK1 and MEK2 inhibitor, with IC50s of 72 nM and 58 nM, respectively. U0126 is an autophagy and mitophagy inhibitor[1][2][3][4].
PRICE
42
DESCRIPTION
U0126-EtOH (U0126 Ethanol) is a non-ATP competitive specific inhibitor of MEK1/2 (IC50: 0.07/0.06 ??M).
DESCRIPTION
U0126 is a potent, non-ATP competitive and selective MEK1 and MEK2 inhibitor, with IC50s of 72 nM and 58 nM, respectively. U0126 is an autophagy and mitophagy inhibitor[1][2][3][4].
DESCRIPTION
U0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD98059.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
U0126-EtOH (U0126 Ethanol) is a non-ATP competitive specific inhibitor of MEK1/2 (IC50: 0.07/0.06 μM).
(TargetMol Bioactive Compound Library)
DESCRIPTION
PDE3 inhibitor
(Tocris Bioactive Compound Library)
DESCRIPTION
U0126 is a MAPK inhibitor with antitumor activity. It inhibits MEK1 and MEK2 with IC50 values of 72 nM and 58 nM, respectively. U0126 inhibits tumorigenicity of liver cancer stem cells.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Potent, selective inhibitor of MEK1 and 2
(Tocriscreen Total)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
6
Organisms
4
Compound Sets
18
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
CZ-OPENSCREEN Bioactive Library
DrugBank
DrugMAP
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
LSP-OptimalKinase library (Laboratory of Systems Pharmacology)
Novartis Chemogenetic Library (NIBR MoA Box)
NURSA ligand set
ReFrame library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Total
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
40
Molecular Weight
380.09
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
4
Rotatable Bonds
5
Ring Count
2
Aromatic Ring Count
2
cLogP
3.12
TPSA
151.66
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.27
QED
0.27
Structural alerts
2
aggregator (Aggregator Advisor)
Aggregators
aggregator (ZINC)
Aggregators
Related compounds
Custom attributes
(extracted from source data)
Target
Autophagy
Influenza Virus
MEK
Mitophagy
Virus Protease
MEK1/2 inhibitor
MEK1
MEK2
MOA
Inhibitor
Apoptosis Inducers
Mitogen-Activated Protein (MAP) Kinase Kinase (MEK) Inhibitors
Extracellular-Regulated Kinase (ERK) Inhibitors
Jak2 Inhibitors
Member status
virtual
Pathway
MAPK
Microbiology/virology
Anti-infection
MAPK/ERK Pathway
Solubility
In Vitro:<br/>DMSO : ≥ 49 mg/mL (114.87 mM)<br/>H2O : < 0.1 mg/mL (insoluble)
In vitro:<br/>10 mM in DMSO
Source data
