General
Preferred name
dolasetron
Synonyms
Anzemet hydrate,MDL-73147EF ()
Dolasetron mesylate ()
Dolasetron mesilate monohydrate ()
Anzemet ()
Dolasetron mesylate monohydrate ()
MDL-73147EF ()
Dolasetron mesilate ()
Dolasetron methanesulfonate ()
MDL 73,147EF ()
Dolasetron mesylate anhydrous ()
Dolasetron Mesylate hydrate ()
P&D ID
PD016336
CAS
115956-13-3
878143-33-0
Tags
available
drug
Drug Status
approved
withdrawn
investigational
Max Phase
4.0
Drug indication
post operative nausea and vomiting
Fibromyalgia
First approval
1997
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
60
DESCRIPTION
Dolasetron Mesylate hydrate (Dalasetron Mesylate Hydrate) , a selective serotonin receptor antagonist, competitively blocks the action of serotonin at 5HT3 receptors, resulting in suppression of chemotherapy- and radiotherapy-induced nausea and vomiting.
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
6
ChEMBL Approved Drugs
ChEMBL Drugs
DrugBank
DrugBank Approved Drugs
Selleckchem Bioactive Compound Library
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
32
Molecular Weight
324.15
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
6
Aromatic Ring Count
2
cLogP
2.52
TPSA
62.4
Fraction CSP3
0.47
Chiral centers
5.0
Largest ring
6.0
QED
0.86
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
5-HT Receptor antagonist
ATC
A04AA04
Toxicity type
cardiovascular
Target
5-HT Receptor
Source data
