General
Preferred name
Monopotassium phosphate
Synonyms
POTASSIUM PHOSPHATE, MONOBASIC ()
Monobasic potassium phosphate ()
Pot Dihydrogen Phos ()
P&D ID
PD016331
CAS
7778-77-0
16068-46-5
Tags
available
inorganic
drug
Drug Status
investigational
approved
vet_approved
Max Phase
Phase 4
Drug indication
Pharmaceutic Aid (buffering agent)
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PHARMACODYNAMICS Potassium is the major cation of intracellular fluid and is essential for maintenance of acid-base balance, isotonicity, and electrodynamic characteristics of the cell. Potassium is an important activator in many enzymatic reactions and is essential to a number of physiologic processes including transmission of nerve impulses; contraction of cardiac, smooth, and skeletal muscles; gastric secretion; renal function; tissue synthesis; and carbohydrate metabolism.; Phosphate is a major intracellular anion that participates in providing energy for metabolism of substrates and contributes to important metabolic and enzymatic reactions in almost all organs and tissues. Phosphate exerts a modifying influence on calcium concentrations, a buffering effect on acid-base equilibrium, and has a major role in the renal excretion of hydrogen ions.
INDICATION Used in buffers (determination of pH, pharmaceutical production, urinary acidifier, paper processing, baking powder, and food), nutrient solutions, yeast foods, special liquid fertilizers, sonar systems and other electronic applications; ; Used as a nutritional supplement in foods, a nonlinear optical material for laser use, and in wastewater treatment;
ROE Renal (90%) and fecal (10%) Phosphates; Potassium is excreted mainly by the kidneys. Small amounts of potassium may be excreted via the skin and intestinal tract, but most of the potassium excreted into the intestine is later reabsorbed.
ABSORPTION Potassium salts are well absorbed from the GI tract. Ingested phosphates are absorbed from the gastrointestinal tract. However, the presence of large amounts of calcium or aluminum may lead to formation of insoluble phosphate and reduce the net absorption. Vitamin D stimulates phosphate absorption.;
TOXICITY Rabbit : LD50 >4640mg/kg (skin); Rat : LdLo : 4640mg/kg (Oral)
Compound Sets
4
ChEMBL Approved Drugs
CHEMBL1200925
ChEMBL Drugs
CHEMBL1200925
DrugBank
DB09413
DrugBank Approved Drugs
DB09413
External IDs
30
Properties
(calculated by RDKit )
Molecular Weight
135.93
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
0
Ring Count
0
Aromatic Ring Count
0
cLogP
-4.56
TPSA
80.59
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
0.0
QED
0.26
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Source data